Loading…
Isoflurane’s Effect on Protein Conformation as a Proposed Mechanism for Preconditioning
Persistent alteration of protein conformation due to interaction with isoflurane may be a novel molecular aspect of preconditioning. We preincubated human serum albumin with isoflurane, dialyzed to release agent, and assessed protein conformation. Susceptibility to chemical modification by methylgly...
Saved in:
| Published in: | Biochemistry Research International 2011-01, Vol.2011 (2011), p.244-251 |
|---|---|
| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-a572t-e36fa27eb67d125e09c90b9d4448099a7758222dae3b5928e830ba0f70fce8cc3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-a572t-e36fa27eb67d125e09c90b9d4448099a7758222dae3b5928e830ba0f70fce8cc3 |
| container_end_page | 251 |
| container_issue | 2011 |
| container_start_page | 244 |
| container_title | Biochemistry Research International |
| container_volume | 2011 |
| creator | Benton, Sean K. Baker, Michelle R. Theisen, Christopher S. McClintick, Chad A. Fibuch, Eugene E. Seidler, Norbert W. |
| description | Persistent alteration of protein conformation due to interaction with isoflurane may be a novel molecular aspect of preconditioning. We preincubated human serum albumin with isoflurane, dialyzed to release agent, and assessed protein conformation. Susceptibility to chemical modification by methylglyoxal and nitrophenylacetate was also examined. Isoflurane had a persistent effect on protein conformation. An increase in the susceptibility of surface residues to chemical modification attended this change in conformation. Modification of isoflurane-treated HSA included intra- and intersubunit cross-linking that may be a consequence of anesthetic-induced changes in multimeric subpopulations. This irreversible effect of isoflurane may represent a mechanism for preconditioning. |
| doi_str_mv | 10.1155/2011/739712 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_d4b91e5d70894f95925704f08bf21d20</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><airiti_id>P20151209002_201112_201706270030_201706270030_244_251</airiti_id><doaj_id>oai_doaj_org_article_d4b91e5d70894f95925704f08bf21d20</doaj_id><sourcerecordid>890679616</sourcerecordid><originalsourceid>FETCH-LOGICAL-a572t-e36fa27eb67d125e09c90b9d4448099a7758222dae3b5928e830ba0f70fce8cc3</originalsourceid><addsrcrecordid>eNqFkk-PEyEYhydG427WPXnWzM1EU_eFgQEuJqZZtUmNe9CDJ8Lwp6WZQoUZjTe_hl_PTyLTWRvXi1yA933yQPhRVY8RvESI0isMCF2xRjCE71XnGAQsMKb0_mlN2Fl1mfMOyiCABCUPqzOMBOIMo_Pq8ypH149JBfvrx89cXztn9VDHUN-kOFgf6mUMLqa9GnwpqlyrqXOI2Zr6vdVbFXze14UoZatjMH4Cfdg8qh441Wd7eTtfVJ_eXH9cvlusP7xdLV-vF4oyPCxs0zqFme1aZhCmFoQW0AlDCOEghGKMcoyxUbbpqMDc8gY6BY6B05Zr3VxUq9lrotrJQ_J7lb7LqLw8FmLaSJUGr3srDekEstQw4II4UXSUAXHAO4eRwVBcr2bXYez21mgbhqT6O9K7neC3chO_ygYxxJgogme3ghS_jDYPcu-ztn1f3jeOWXIBLRMtagv5YiZ1ijkn606nIJBTtHKKVs7RFvrp3xc7sX-CLMDzGdj6YNQ3_x_bkxm2BbFOnWAiCOeTbD33lU8lTrmLYwolQ3lTLBRNPwvw0YiOE4MWM4AG_tkQIjFFzW9DLMo0</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>890679616</pqid></control><display><type>article</type><title>Isoflurane’s Effect on Protein Conformation as a Proposed Mechanism for Preconditioning</title><source>Wiley-Blackwell Open Access Collection</source><source>PubMed Central</source><creator>Benton, Sean K. ; Baker, Michelle R. ; Theisen, Christopher S. ; McClintick, Chad A. ; Fibuch, Eugene E. ; Seidler, Norbert W.</creator><contributor>Creamer, Trevor</contributor><creatorcontrib>Benton, Sean K. ; Baker, Michelle R. ; Theisen, Christopher S. ; McClintick, Chad A. ; Fibuch, Eugene E. ; Seidler, Norbert W. ; Creamer, Trevor</creatorcontrib><description>Persistent alteration of protein conformation due to interaction with isoflurane may be a novel molecular aspect of preconditioning. We preincubated human serum albumin with isoflurane, dialyzed to release agent, and assessed protein conformation. Susceptibility to chemical modification by methylglyoxal and nitrophenylacetate was also examined. Isoflurane had a persistent effect on protein conformation. An increase in the susceptibility of surface residues to chemical modification attended this change in conformation. Modification of isoflurane-treated HSA included intra- and intersubunit cross-linking that may be a consequence of anesthetic-induced changes in multimeric subpopulations. This irreversible effect of isoflurane may represent a mechanism for preconditioning.</description><identifier>ISSN: 2090-2247</identifier><identifier>EISSN: 2090-2255</identifier><identifier>DOI: 10.1155/2011/739712</identifier><identifier>PMID: 21918721</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Limiteds</publisher><ispartof>Biochemistry Research International, 2011-01, Vol.2011 (2011), p.244-251</ispartof><rights>Copyright © 2011 Michelle R. Baker et al.</rights><rights>Copyright © 2011 Michelle R. Baker et al. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a572t-e36fa27eb67d125e09c90b9d4448099a7758222dae3b5928e830ba0f70fce8cc3</citedby><cites>FETCH-LOGICAL-a572t-e36fa27eb67d125e09c90b9d4448099a7758222dae3b5928e830ba0f70fce8cc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171779/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171779/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21918721$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Creamer, Trevor</contributor><creatorcontrib>Benton, Sean K.</creatorcontrib><creatorcontrib>Baker, Michelle R.</creatorcontrib><creatorcontrib>Theisen, Christopher S.</creatorcontrib><creatorcontrib>McClintick, Chad A.</creatorcontrib><creatorcontrib>Fibuch, Eugene E.</creatorcontrib><creatorcontrib>Seidler, Norbert W.</creatorcontrib><title>Isoflurane’s Effect on Protein Conformation as a Proposed Mechanism for Preconditioning</title><title>Biochemistry Research International</title><addtitle>Biochem Res Int</addtitle><description>Persistent alteration of protein conformation due to interaction with isoflurane may be a novel molecular aspect of preconditioning. We preincubated human serum albumin with isoflurane, dialyzed to release agent, and assessed protein conformation. Susceptibility to chemical modification by methylglyoxal and nitrophenylacetate was also examined. Isoflurane had a persistent effect on protein conformation. An increase in the susceptibility of surface residues to chemical modification attended this change in conformation. Modification of isoflurane-treated HSA included intra- and intersubunit cross-linking that may be a consequence of anesthetic-induced changes in multimeric subpopulations. This irreversible effect of isoflurane may represent a mechanism for preconditioning.</description><issn>2090-2247</issn><issn>2090-2255</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNqFkk-PEyEYhydG427WPXnWzM1EU_eFgQEuJqZZtUmNe9CDJ8Lwp6WZQoUZjTe_hl_PTyLTWRvXi1yA933yQPhRVY8RvESI0isMCF2xRjCE71XnGAQsMKb0_mlN2Fl1mfMOyiCABCUPqzOMBOIMo_Pq8ypH149JBfvrx89cXztn9VDHUN-kOFgf6mUMLqa9GnwpqlyrqXOI2Zr6vdVbFXze14UoZatjMH4Cfdg8qh441Wd7eTtfVJ_eXH9cvlusP7xdLV-vF4oyPCxs0zqFme1aZhCmFoQW0AlDCOEghGKMcoyxUbbpqMDc8gY6BY6B05Zr3VxUq9lrotrJQ_J7lb7LqLw8FmLaSJUGr3srDekEstQw4II4UXSUAXHAO4eRwVBcr2bXYez21mgbhqT6O9K7neC3chO_ygYxxJgogme3ghS_jDYPcu-ztn1f3jeOWXIBLRMtagv5YiZ1ijkn606nIJBTtHKKVs7RFvrp3xc7sX-CLMDzGdj6YNQ3_x_bkxm2BbFOnWAiCOeTbD33lU8lTrmLYwolQ3lTLBRNPwvw0YiOE4MWM4AG_tkQIjFFzW9DLMo0</recordid><startdate>20110101</startdate><enddate>20110101</enddate><creator>Benton, Sean K.</creator><creator>Baker, Michelle R.</creator><creator>Theisen, Christopher S.</creator><creator>McClintick, Chad A.</creator><creator>Fibuch, Eugene E.</creator><creator>Seidler, Norbert W.</creator><general>Hindawi Limiteds</general><general>Hindawi Puplishing Corporation</general><general>Hindawi Publishing Corporation</general><general>Hindawi Limited</general><scope>188</scope><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20110101</creationdate><title>Isoflurane’s Effect on Protein Conformation as a Proposed Mechanism for Preconditioning</title><author>Benton, Sean K. ; Baker, Michelle R. ; Theisen, Christopher S. ; McClintick, Chad A. ; Fibuch, Eugene E. ; Seidler, Norbert W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a572t-e36fa27eb67d125e09c90b9d4448099a7758222dae3b5928e830ba0f70fce8cc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Benton, Sean K.</creatorcontrib><creatorcontrib>Baker, Michelle R.</creatorcontrib><creatorcontrib>Theisen, Christopher S.</creatorcontrib><creatorcontrib>McClintick, Chad A.</creatorcontrib><creatorcontrib>Fibuch, Eugene E.</creatorcontrib><creatorcontrib>Seidler, Norbert W.</creatorcontrib><collection>Chinese Electronic Periodical Services (CEPS)</collection><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Biochemistry Research International</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Benton, Sean K.</au><au>Baker, Michelle R.</au><au>Theisen, Christopher S.</au><au>McClintick, Chad A.</au><au>Fibuch, Eugene E.</au><au>Seidler, Norbert W.</au><au>Creamer, Trevor</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Isoflurane’s Effect on Protein Conformation as a Proposed Mechanism for Preconditioning</atitle><jtitle>Biochemistry Research International</jtitle><addtitle>Biochem Res Int</addtitle><date>2011-01-01</date><risdate>2011</risdate><volume>2011</volume><issue>2011</issue><spage>244</spage><epage>251</epage><pages>244-251</pages><issn>2090-2247</issn><eissn>2090-2255</eissn><abstract>Persistent alteration of protein conformation due to interaction with isoflurane may be a novel molecular aspect of preconditioning. We preincubated human serum albumin with isoflurane, dialyzed to release agent, and assessed protein conformation. Susceptibility to chemical modification by methylglyoxal and nitrophenylacetate was also examined. Isoflurane had a persistent effect on protein conformation. An increase in the susceptibility of surface residues to chemical modification attended this change in conformation. Modification of isoflurane-treated HSA included intra- and intersubunit cross-linking that may be a consequence of anesthetic-induced changes in multimeric subpopulations. This irreversible effect of isoflurane may represent a mechanism for preconditioning.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Limiteds</pub><pmid>21918721</pmid><doi>10.1155/2011/739712</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2090-2247 |
| ispartof | Biochemistry Research International, 2011-01, Vol.2011 (2011), p.244-251 |
| issn | 2090-2247 2090-2255 |
| language | eng |
| recordid | cdi_doaj_primary_oai_doaj_org_article_d4b91e5d70894f95925704f08bf21d20 |
| source | Wiley-Blackwell Open Access Collection; PubMed Central |
| title | Isoflurane’s Effect on Protein Conformation as a Proposed Mechanism for Preconditioning |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T14%3A40%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Isoflurane%E2%80%99s%20Effect%20on%20Protein%20Conformation%20as%20a%20Proposed%20Mechanism%20for%20Preconditioning&rft.jtitle=Biochemistry%20Research%20International&rft.au=Benton,%20Sean%20K.&rft.date=2011-01-01&rft.volume=2011&rft.issue=2011&rft.spage=244&rft.epage=251&rft.pages=244-251&rft.issn=2090-2247&rft.eissn=2090-2255&rft_id=info:doi/10.1155/2011/739712&rft_dat=%3Cproquest_doaj_%3E890679616%3C/proquest_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-a572t-e36fa27eb67d125e09c90b9d4448099a7758222dae3b5928e830ba0f70fce8cc3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=890679616&rft_id=info:pmid/21918721&rft_airiti_id=P20151209002_201112_201706270030_201706270030_244_251&rfr_iscdi=true |