A rare gynecologic presentation of proteus syndrome: A case report

• Published in: Case reports in women's health 2022-01, Vol.33, p.e00373, Article e00373
• Main Authors: Abouzeid, Bassel, Buck, Amanda, Haikal, Samantha, Elkattah, Rayan
• Format: Article
• Language: English
• Subjects: Gynecology; Hysterectomy; Prolapse; proteus; Rare genetic
• ISSN: 2214-9112; 2214-9112
• DOI: 10.1016/j.crwh.2021.e00373

Proteus syndrome is a genetic condition with an estimated incidence of less than one in a million. This condition is sporadic and presents as progressive, mosaic overgrowth of different tissues. Clinical manifestations are diverse, with the reported involvement of lungs, skin, blood cells, the nervous system and bones. Gynecologic manifestations have rarely been reported in the literature. This case is the first to be reported in the literature of a woman with Proteus syndrome diagnosed in her prepubertal years and presenting at 34 years old with a cervical mass protruding from the vagina. The patient sought medical intervention only after the prolapse was advanced and symptomatic. Management of this case was surgical and consisted of vaginal hysterectomy, with vaginal suspension. •Proteus syndrome is a rare genetic, sporadic syndrome characterized by progressive overgrowth of tissue.•Gynecologic manifestations of Proteus syndrome have an incidence of about 1 in a million.•Rare case of vaginal prolapse for a cervical mass for a patient with Proteus syndrome.