Production of Terretonin N and Butyrolactone I by Thermophilic Aspergillus terreus TM8 Promoted Apoptosis and Cell Death in Human Prostate and Ovarian Cancer Cells

The anticancer activity of terretonin N (1) and butyrolactone I (2), obtained from the thermophilic fungus Aspergillus terreus TM8, was intensively studied against prostate adenocarcinoma (PC-3) and ovary adenocarcinoma (SKOV3) human cell lines. According to this study, both compounds showed potent...

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Published in:Molecules (Basel, Switzerland) Switzerland), 2021-05, Vol.26 (9), p.2816
Main Authors: Ghfar, Ayman, El-Metwally, Mohammad, Shaaban, Mohamed, Gabr, Sami, Gabr, Nada, Diab, Marwa, Aqel, Ahmad, Habila, Mohamed, Al-Qahtani, Wahidah, Alfaifi, Mohammad, Elbehairi, Serag, AlJumah, Bayan
Format: Article
Language:English
Subjects:
Adenocarcinoma
anticancer activity
Antitumor activity
Apoptosis
Aspergillus terreus
Aspergillus terreus TM8
Biological properties
Butyrolactone
butyrolactone I
Cell death
Chromatography
Cyclin-dependent kinases
Cytotoxicity
Fungi
Kinases
Medical research
Metabolites
Metastases
Metastasis
Natural products
Ovarian cancer
PC-3
Prostate
Prostate cancer
SKOV3
terretonin N
Thermophilic fungi
Tumor cell lines
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Summary:The anticancer activity of terretonin N (1) and butyrolactone I (2), obtained from the thermophilic fungus Aspergillus terreus TM8, was intensively studied against prostate adenocarcinoma (PC-3) and ovary adenocarcinoma (SKOV3) human cell lines. According to this study, both compounds showed potent cytotoxicity towards ovarian adenocarcinoma cells (SKOV3) with IC50 1.2 and 0.6 μg/mL, respectively. With respect to metastatic prostate cells (PC-3), the two compounds 1 and 2 showed a significantly promising cytotoxicity effect with IC50 of 7.4 and 4.5 μg/mL, respectively. The tested fungal metabolites showed higher rates of early and late apoptosis with little or no necrotic apoptotic pathway in all treated prostate adenocarcinoma (PC-3) and ovary adenocarcinoma (SKOV3) human cell lines, respectively. The results reported in this study confirmed the promising biological properties of terretonin N (1) and butyrolactone I (2) as anticancer agents via the induction of cellular apoptosis. However, further studies are needed to elucidate the molecular mechanism by which cellular apoptosis is induced in cancer cells.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules26092816