The prognostic value of arginase-1 and glypican-3 expression levels in patients after surgical intrahepatic cholangiocarcinoma resection

The aim of this study was to investigate the prognostic value of arginase-1 (Arg-1) and glypican-3 (GPC-3) in patients with intrahepatic cholangiocarcinoma (ICC). Two hundred and thirty-seven patients with ICC were included in this study. All patients had undergone radical surgery and had complete c...

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Bibliographic Details
Published in:World journal of surgical oncology 2021-10, Vol.19 (1), p.316-316, Article 316
Main Authors: Qiang, Zeyuan, Zhang, Haofeng, Jin, Shuai, Yan, Cao, Li, Zhen, Tao, Lianyuan, Yu, Haibo
Format: Article
Language:English
Subjects:
Antibodies
Arginase
Arginase-1
Bile Duct Neoplasms - surgery
Biological markers
Biomarkers
Cancer therapies
Cholangiocarcinoma
Cholangiocarcinoma - surgery
Excision (Surgery)
Glycoproteins
Glypican-3
Glypicans
Health aspects
Heparan sulfate proteoglycans
Humans
Immunohistochemistry
Infections
Intrahepatic cholangiocarcinoma
Liver cancer
Lymphatic system
Medical prognosis
Metastasis
Patient outcomes
Patients
Prognosis
Risk analysis
Risk factors
Signal transduction
Surgery
Tumors
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Summary:The aim of this study was to investigate the prognostic value of arginase-1 (Arg-1) and glypican-3 (GPC-3) in patients with intrahepatic cholangiocarcinoma (ICC). Two hundred and thirty-seven patients with ICC were included in this study. All patients had undergone radical surgery and had complete clinical information. Immunohistochemistry was used to assess the levels of Arg-1 and GPC-3 in ICC tissues. Univariate and multivariate analyses were conducted to identify independent risk factors in ICC. The relationship between Arg-1 and GPC-3 levels and patient survival was determined using the Kaplan-Meier method. High Arg-1 and GPC-3 expression levels were associated with poor prognosis in patients with ICC, and they could be as new prognostic biomarkers in ICC. Arg-1 and GPC-3 can serve as independent prognostic biomarkers in ICC.
ISSN:1477-7819
1477-7819
DOI:10.1186/s12957-021-02426-9