Effectiveness and Efficacy of Vaccine on Mutated SARS-CoV-2 Virus and Post Vaccination Surveillance: A Narrative Review

The ongoing COVID-19 pandemic, as a result of the SARS-CoV-2 virus, since December 2019, is a major health problem and concern worldwide. The pandemic has impacted various fields, from the social to the development of health science and technology. The virus has been mutating and thus producing seve...

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Bibliographic Details
Published in:Vaccines (Basel) 2022-01, Vol.10 (1), p.82
Main Authors: Hafiz, Ihsanul, Illian, Didi Nurhadi, Meila, Okpri, Utomo, Ahmad Rusdan Handoyo, Susilowati, Arida, Susetya, Ipanna Enggar, Desrita, Desrita, Siregar, Gontar Alamsyah, Basyuni, Mohammad
Format: Article
Language:English
Subjects:
Amino acids
Coronaviruses
COVID-19
COVID-19 vaccines
Disease transmission
Genomes
Glycoproteins
Microscopy
Middle East respiratory syndrome
Molecular biology
mutated SARS-CoV-2 virus
Mutation
Pandemics
post vaccine surveillance
Proteins
Review
Severe acute respiratory syndrome coronavirus 2
Surveillance
vaccine
Vaccines
Viral diseases
Viruses
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Summary:The ongoing COVID-19 pandemic, as a result of the SARS-CoV-2 virus, since December 2019, is a major health problem and concern worldwide. The pandemic has impacted various fields, from the social to the development of health science and technology. The virus has been mutating and thus producing several new variants, rushing research in the field of molecular biology to develop rapidly to overcome the problems that occur. Vaccine clinical studies are developing promptly with the aim of obtaining vaccines that are effective in suppressing the spread of the virus; however, the development of viral mutations raises concerns about the decreasing effectiveness of the resulting vaccine, which also results in the need for more in-depth studies. There have been 330 vaccines developed, including 136 clinical developments and 194 pre-clinical developments. The SARS-CoV-2 variant continues to evolve today, and it poses a challenge in testing the effectiveness of existing vaccines. This is a narrative review describing the emergence of the COVID-19 pandemic, development of vaccine platforms, identification of concerning mutations and virus variants in various countries of the world, and real-world monitoring of post-vaccination effectiveness and surveillance.
ISSN:2076-393X
2076-393X
DOI:10.3390/vaccines10010082