Weight Loss and Malnutrition in Patients with Parkinson's Disease: Current Knowledge and Future Prospects

Parkinson's Disease (PD) is currently considered a systemic neurodegenerative disease manifested with not only motor but also non-motor symptoms. In particular, weight loss and malnutrition, a set of frequently neglected non-motor symptoms, are indeed negatively associated with the life quality...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in aging neuroscience 2018-01, Vol.10, p.1-1
Main Authors: Ma, Kai, Xiong, Nian, Shen, Yan, Han, Chao, Liu, Ling, Zhang, Guoxin, Wang, Luxi, Guo, Shiyi, Guo, Xingfang, Xia, Yun, Wan, Fang, Huang, Jinsha, Lin, Zhicheng, Wang, Tao
Format: Article
Language:English
Subjects:
Body mass index
Body weight
Body weight loss
Circadian rhythms
Energy balance
energy homeostasis
Kinases
Malnutrition
Morbidity
Movement disorders
Neurodegeneration
Neurodegenerative diseases
Neuroscience
Nutritional status
Parkinson's disease
Quality of life
weight evaluation
weight loss
weight management
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Parkinson's Disease (PD) is currently considered a systemic neurodegenerative disease manifested with not only motor but also non-motor symptoms. In particular, weight loss and malnutrition, a set of frequently neglected non-motor symptoms, are indeed negatively associated with the life quality of PD patients. Moreover, comorbidity of weight loss and malnutrition may impact disease progression, giving rise to dyskinesia, cognitive decline and orthostatic hypotension, and even resulting in disability and mortality. Nevertheless, the underlying mechanism of weight loss and malnutrition in PD remains obscure and possibly involving multitudinous, exogenous or endogenous, factors. What is more, there still does not exist any weight loss and malnutrition appraision standards and management strategies. Given this, here in this review, we elaborate the weight loss and malnutrition study status in PD and summarize potential determinants and mechanisms as well. In conclusion, we present current knowledge and future prospects of weight loss and malnutrition in the context of PD, aiming to appeal clinicians and researchers to pay a closer attention to this phenomena and enable better management and therapeutic strategies in future clinical practice.
ISSN:1663-4365
1663-4365
DOI:10.3389/fnagi.2018.00001