Immune infiltration correlates with transcriptomic subtypes in primary estrogen receptor positive invasive lobular breast cancer

Understanding interplay of breast cancer and microenvironment is critical. Here we identified two transcriptomic subtypes and five immune infiltration patterns from RNA-seq and multiplex immunohistochemistry from 21 ER + /HER2- ILCs. We found proliferative subtype associated with increased suppressi...

Full description

Saved in:
Bibliographic Details
Published in:NPJ precision oncology 2024-11, Vol.8 (1), p.257-8, Article 257
Main Authors: Chen, Fangyuan, Onkar, Sayali, Zou, Jian, Li, Yujia, Arbore, Haley, Maley, Sai, Tseng, George, Lucas, Peter C., Bruno, Tullia C., Vignali, Dario A. A., Foldi, Julia, Balic, Marija, Lee, Adrian V., Oesterreich, Steffi
Format: Article
Language:English
Subjects:
631/67/1347
692/4028/67/1347
Biomarkers
Breast cancer
Brief Communication
Cancer Research
Cells
Estrogens
Gene expression
Gene Therapy
Human Genetics
Immunohistochemistry
Internal Medicine
Kinases
Lymphocytes
Medical prognosis
Medical research
Medicine
Medicine & Public Health
Oncology
Tumors
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Understanding interplay of breast cancer and microenvironment is critical. Here we identified two transcriptomic subtypes and five immune infiltration patterns from RNA-seq and multiplex immunohistochemistry from 21 ER + /HER2- ILCs. We found proliferative subtype associated with increased suppressive immune infiltration, and defined a signature associated with lower proliferative, pro-inflammatory TAM infiltration, and improved survival in ER+ breast cancer. Our work identified genes related to ILC immune microenvironment and prognosis.
ISSN:2397-768X
2397-768X
DOI:10.1038/s41698-024-00746-z