Vitamin D receptor gene polymorphism and left ventricular hypertrophy in chronic kidney disease

FokI and BsmI polymorphisms of vitamin D receptor (VDR) gene are regarded as reliable markers of disturbed vitamin D signaling pathway. Left ventricular hypertrophy (LVH) is a strong cardiovascular risk marker in end stage renal disease (ESRD) patients. Since BsmI polymorphism has been associated wi...

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Bibliographic Details
Published in:Nutrients 2014-03, Vol.6 (3), p.1029-1037
Main Authors: Santoro, Domenico, Gagliostro, Giorgia, Alibrandi, Angela, Ientile, Riccardo, Bellinghieri, Guido, Savica, Vincenzo, Buemi, Michele, Caccamo, Daniela
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Alleles
chronic kidney disease
Cohort Studies
Creatinine
Diabetes
Electronic mail systems
Female
gene polymorphisms
Genotype
Genotype & phenotype
Hemodialysis
Hemodynamics
Humans
Hypertension
Hypertrophy, Left Ventricular - complications
Hypertrophy, Left Ventricular - genetics
Kidney diseases
left ventricular hypertrophy
Male
Middle Aged
parathormone
Polymorphism
Polymorphism, Genetic
Receptors, Calcitriol - genetics
Renal Dialysis
Renal Insufficiency, Chronic - complications
Renal Insufficiency, Chronic - genetics
Risk Factors
Signal Transduction
Vitamin D
vitamin D receptor
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Summary:FokI and BsmI polymorphisms of vitamin D receptor (VDR) gene are regarded as reliable markers of disturbed vitamin D signaling pathway. Left ventricular hypertrophy (LVH) is a strong cardiovascular risk marker in end stage renal disease (ESRD) patients. Since BsmI polymorphism has been associated with LVH in ESRD patients, we addressed this study in patients with chronic kidney disease (CKD) not yet on dialysis. One hundred and forty five patients with CKD stage 3 were genotyped for FokI and BsmI VDR polymorphisms, in order to assess the relationships between these VDR polymorphisms, some markers of mineral bone disorders, and LVH measured by echocardiography. Patients bearing either the Ff heterozygous or FF homozygous genotype had significantly higher PTH values than those bearing the ff genotype. The relationships between VDR genotypes and LVH revealed a highly significant association of the BsmI Bb heterozygous genotype with LVH. In patients with CKD stage 3 BsmI B allele was independently related to LVH. Since LVH is a frequent finding in dialysis population due to several mechanisms, the presence of the same relationship in patients with CKD strengthens the hypothesis that alterations of vitamin D signaling are implicated in LVH development in patients with renal diseases.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu6031029