Insulin, aging, and the brain: mechanisms and implications

There is now an impressive body of literature implicating insulin and insulin signaling in successful aging and longevity. New information from in vivo and in vitro studies concerning insulin and insulin receptors has extended our understanding of the physiological role of insulin in the brain. Howe...

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Bibliographic Details
Published in:Frontiers in endocrinology (Lausanne) 2015-02, Vol.6, p.13-13
Main Authors: Akintola, Abimbola A, van Heemst, Diana
Format: Article
Language:English
Subjects:
accelerated aging
Brain
Endocrinology
Inflammation
Insulin
insulin receptors
longevity
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Summary:There is now an impressive body of literature implicating insulin and insulin signaling in successful aging and longevity. New information from in vivo and in vitro studies concerning insulin and insulin receptors has extended our understanding of the physiological role of insulin in the brain. However, the relevance of these to aging and longevity remains to be elucidated. Here, we review advances in our understanding of the physiological role of insulin in the brain, how insulin gets into the brain, and its relevance to aging and longevity. Furthermore, we examine possible future therapeutic applications and implications of insulin in the context of available models of delayed and accelerated aging.
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2015.00013