A regulatory role for CD72 expression on B cells and increased soluble CD72 in primary Sjogren's syndrome

CD72, a co-receptor of B cell receptor (BCR), has been reported to have both positive and negative effects on B cell functions in several immunological diseases. The B cell plays an important role in the pathogenesis of primary Sjogren's syndrome (pSS). However, whether CD72 is involved in the...

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Bibliographic Details
Published in:BMC immunology 2020-04, Vol.21 (1), p.21-21, Article 21
Main Authors: Shen, Yuqi, Ma, Yuhua, Xie, Jingyuan, Lin, Li, Shi, Yifan, Li, Xiao, Shen, Pingyan, Pan, Xiaoxia, Ren, Hong
Format: Article
Language:English
Subjects:
Antibodies
Antigens
Autoimmune diseases
B cells
B-cell receptor
CD72 antigen
CD72 expression on B cell
Cell growth
Disease
Exocrine glands
Hyperactivity
Immunoglobulin G
Immunological diseases
Kinases
Ligands
Lymphocytes B
Lymphoma
Multiple sclerosis
Pathogenesis
Primary Sjogren’s syndrome
Serum IgG level
Serum soluble CD72 level
Sjogren's syndrome
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Summary:CD72, a co-receptor of B cell receptor (BCR), has been reported to have both positive and negative effects on B cell functions in several immunological diseases. The B cell plays an important role in the pathogenesis of primary Sjogren's syndrome (pSS). However, whether CD72 is involved in the process remains unknown. This study aimed to observe the possible role of CD72 in the pathogenesis of pSS. A total of 60 cases who fulfilled the American-European Consensus Group (AECG) criteria for the diagnosis of pSS and 61 gender and age-matched healthy controls were recruited in this study. The percentage of CD72+ B cells was 85.31 ± 8.37% in pSS patients and 76.91 ± 8.50% in healthy controls(p 
ISSN:1471-2172
1471-2172
DOI:10.1186/s12865-020-00351-2