Clinical implications and molecular mechanisms of Cyclin-dependent kinases 4 for patients with hepatocellular carcinoma

Hepatocellular carcinoma (HCC) was frequently considered as a kind of malignant tumor with a poor prognosis. Cyclin-dependent kinases (CDK) 4 was considered to be cell-cycle-related CDK gene. In this study, we explored the clinical significance of CDK4 in HCC patients. Data of HCC patients were obta...

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Published in:BMC gastroenterology 2022-02, Vol.22 (1), p.77-77, Article 77
Main Authors: Wei, Zhong-Liu, Zhou, Xin, Lan, Chen-Lu, Huang, Hua-Sheng, Liao, Xi-Wen, Mo, Shu-Tian, Wei, Yong-Guang, Peng, Tao
Format: Article
Language:English
Subjects:
Analysis
Biomarker
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
Cancer
Carcinoma, Hepatocellular - pathology
Care and treatment
Cyclin-dependent kinases
Diagnosis
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Genetic aspects
Genetic transcription
Hepatocellular carcinoma
Hepatoma
Humans
Kaplan-Meier Estimate
Liver Neoplasms - pathology
Methods
Molecular mechanics
Prognosis
Risk factors
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Summary:Hepatocellular carcinoma (HCC) was frequently considered as a kind of malignant tumor with a poor prognosis. Cyclin-dependent kinases (CDK) 4 was considered to be cell-cycle-related CDK gene. In this study, we explored the clinical significance of CDK4 in HCC patients. Data of HCC patients were obtained from The Cancer Genome Atlas database (TCGA) and the Gene Expression Omnibus (GEO) database. Kaplan-Meier analysis and Cox regression model were performed to calculate median survival time (MST) and the hazard ration (HR), respectively. The joint-effect analysis and prognostic risk score model were constructed to demonstrate significance of prognosis-related genes. The differential expression of prognostic genes was further validated using reverse transcription-quantitative PCR (RT-qPCR) of 58 pairs of HCC samples. CDK1 and CDK4 were considered prognostic genes in TCGA and GSE14520 cohort. The result of joint-effect model indicated patients in CDK1 and CDK4 low expression groups had a better prognosis in TCGA (adjusted HR = 0.491; adjusted P = 0.003) and GSE14520 cohort (adjusted HR = 0.431; adjusted P = 0.002). Regarding Kaplan-Meier analysis, high expression of CDK1 and CDK4 was related to poor prognosis in both the TCGA (P 
ISSN:1471-230X
1471-230X
DOI:10.1186/s12876-022-02152-w