The role of LOXL2 in tumor progression, immune response and cellular senescence: a comprehensive analysis

LOXL2 , an enzyme belonging to the LOX family, facilitates the cross-linking of extracellular matrix (ECM) elements. However, the roles of the LOXL2 gene in mechanisms of oncogenesis and tumor development have not been clearly defined. In this pan-cancer study, we examined the notable disparity in L...

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Bibliographic Details
Published in:Discover. Oncology 2024-06, Vol.15 (1), p.245-18, Article 245
Main Authors: Ye, Chen, Jiang, Sihan, Zeng, Tanlun, He, Shaohui, Cao, Jinjin, Xiao, Jianru
Format: Article
Language:English
Subjects:
Analysis
Biomarkers
Brain cancer
Breast cancer
Cancer Research
Cancer therapies
Cellular senescence
Colorectal cancer
Genes
Immunity
Immunotherapy
Internal Medicine
Liver cancer
LOXL2
Medical prognosis
Medicine
Medicine & Public Health
Metastasis
Molecular Medicine
Mutation
Oncology
Pan-cancer analysis
Pathogenesis
Prognosis
Protein expression
Proteins
Radiotherapy
Senescence
Surgical Oncology
Survival analysis
Tumors
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Summary:LOXL2 , an enzyme belonging to the LOX family, facilitates the cross-linking of extracellular matrix (ECM) elements. However, the roles of the LOXL2 gene in mechanisms of oncogenesis and tumor development have not been clearly defined. In this pan-cancer study, we examined the notable disparity in LOXL2 expression at the mRNA and protein levels among various cancer types and elucidated its interconnected roles in tumor progression, mutational profile, immune response, and cellular senescence. Apart from investigating the hyperexpression of LOXL2 being related to poorer prognosis in different types of tumors, this study also unveiled noteworthy connections between LOXL2 and genetic mutations, infiltration of tumor immune cells, and genes in immune checkpoint pathways. Further analysis revealed the participation of LOXL2 in multiple pathways related to cancer extracellular matrix remodeling and cellular senescence. Moreover, our investigation uncovered that the knockdown and inhibition of LOXL2 significantly attenuated the proliferation and migration of PC-9 and HCC-LM3 cells. The knock-down and inhibition of LOXL2 enhanced cellular senescence in lung and liver cancer cells, as confirmed by SA-β-Gal staining and quantitative RT-PCR analyses. This comprehensive analysis offers valuable insights on the functions of LOXL2 in different types of cancer and its role in regulating the senescence of cancer cells.
ISSN:2730-6011
2730-6011
DOI:10.1007/s12672-024-01107-9