Ameliorative effect of ethanolic extract of Carica papaya leaves on hyper-cholesterolemic rats: The egg yolk induced model

Cardiovascular disease is one of the leading killers in the world today, and hyperlipidemia is one of the main risk factors. The prevalence of hyperlipidemia is rising dramatically worldwide and is mostly felt in poorer nations. The majority of communities and individuals in Africa are known to turn...

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Bibliographic Details
Published in:Heliyon 2023-06, Vol.9 (6), p.e17379-e17379, Article e17379
Main Authors: Ademuyiwa, Oluwaseun Hannah, Fasogbon, Beatrice Mofoluwaso, Bamidele, Oluwaseun Peter, Ukpo, Grace Eigbibhalu
Format: Article
Language:English
Subjects:
Acacia
Africa
albino
bioactive compounds
cardiovascular diseases
Carica papaya
Cholesterol
egg yolk
eggs
Ethanolic extracts
fenofibrate
fruits
functional foods
high density lipoprotein cholesterol
Hypercholesterolemia
Hyperlipidaemia
low density lipoprotein cholesterol
Pawpaw leaf
risk
traditional medicine
Triglycerides
tropical plants
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Summary:Cardiovascular disease is one of the leading killers in the world today, and hyperlipidemia is one of the main risk factors. The prevalence of hyperlipidemia is rising dramatically worldwide and is mostly felt in poorer nations. The majority of communities and individuals in Africa are known to turn to ethnomedicine for their medical requirements. The tropical plant Carica papaya, which is grown for its edible, ripe fruit in Africa, was used in folk medicine for treatment of cardiovascular issues as well as a number of serious illnesses. This study assessed the anticholesterolemic property of the ethanolic extracts of Carica papaya leaves, adapting the egg yolk-induced hyperlipidaemia model in Wistar albino rats. This study prepared egg yolk to induce hyperlipidaemia in the Wistar rats, then treated some groups with the extract of Carica papaya leaves, and other groups with the standard drug Fenofibrate. The Wistar rats in the control group were given 2% acacia instead of egg yolk. The total cholesterol, triglycerides, as well as biological and haematological parameters, were determined. The Carica papaya leaves extracts significantly (p 250 mg/kg > Fenofibrate (2.29 mg/kg) > 500 mg/kg. With the potential efficacy of Carica papaya leaves extract in the treatment of hypercholesterolemia and, as a result, cardiovascular diseases, more research on bioactive molecule isolation/characterisation for pharmaceutical use or incorporation into functional food products for CVD management is required.
ISSN:2405-8440
2405-8440
DOI:10.1016/j.heliyon.2023.e17379