Associations between fibrinogen levels and the risk of cardiovascular disease and all-cause death: a cohort study from the Chin-Shan community in Taiwan

ObjectivesAlthough several studies have investigated the association between fibrinogen level and the risk of cardiovascular disease (CVD), few studies have been conducted in Asia.SettingWe conducted a community-based prospective cohort study in the Chin-Shan community, Taiwan.ParticipantsA total of...

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Bibliographic Details
Published in:BMJ open 2022-04, Vol.12 (4), p.e054638-e054638
Main Authors: Hsieh, Cheng-Tzu, Chien, Kuo-Liong, Hsu, Hsiu-Ching, Lin, Hung-Ju, Su, Ta-Chen, Chen, Ming-Fong, Lee, Yuan-Teh
Format: Article
Language:English
Subjects:
Biomarkers
Cardiovascular disease
Cardiovascular Diseases - etiology
Chin
Cohort analysis
Cohort Studies
coronary heart disease
Epidemiology
Female
Fibrinogen - metabolism
Health risks
Humans
Male
Prospective Studies
Proteins
Stroke
Taiwan - epidemiology
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Summary:ObjectivesAlthough several studies have investigated the association between fibrinogen level and the risk of cardiovascular disease (CVD), few studies have been conducted in Asia.SettingWe conducted a community-based prospective cohort study in the Chin-Shan community, Taiwan.ParticipantsA total of 2222 participants (54.6±11.9 years, 53.4% women, and 22.4 years of follow-up) who underwent plasma fibrinogen measurements and were without CVD at baseline were recruited, among which 735 participants with available C reactive protein (CRP) were included in the joint analysis of the association of fibrinogen and CRP levels with the risk of CVD.Primary and secondary outcome measuresFibrinogen and CRP levels were measured by clotting and high-sensitivity immunoturbidimetric assays, respectively. The study outcomes were CVD events and all-cause death. Our definition of CVD included both coronary artery disease (CAD) and stroke cases. Cox proportional hazards regression models were used to estimate the HRs and 95% CIs.ResultsCompared with the lowest quartile, participants with higher fibrinogen levels tended to have a higher risk of CAD (adjusted HR for the highest quartile=1.48 (95% CI 0.90 to 2.44); test for trend p=0.037) regardless of CRP level (adjusted HR=2.12 (95% CI 1.24 to 3.63) and 2.17 (95% CI 1.06 to 4.44) for high fibrinogen/low CRP and high fibrinogen/high CRP, respectively). The association was not observed for stroke (adjusted HR for the highest quartile=0.99 (95% CI 0.62 to 1.60); test for trend p=0.99) and was only observed for all-cause death among participants
ISSN:2044-6055
2044-6055
DOI:10.1136/bmjopen-2021-054638