Placental Implications of Peroxisome Proliferator-Activated Receptors in Gestation and Parturition

The placenta is a transitory structure indispensable for the proper development of the embryo and fetus during mammalian gestation. Like other members of the nuclear receptor family, the peroxisome proliferator-activated receptors (PPARs) are known to be involved in the physiological and pathologica...

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Bibliographic Details
Published in:PPAR Research 2008-01, Vol.2008 (2008), p.4-12-101
Main Authors: Borel, Valerie, Gallot, Denis, Marceau, Geoffroy, Sapin, Vincent, Blanchon, Loïc
Format: Article
Language:English
Subjects:
Genes
Gynecology and obstetrics
Human health and pathology
Life Sciences
Membranes
Metabolites
Molecular weight
Pathology
Preeclampsia
Proteins
Reproductive Biology
Review
Sexual reproduction
Studies
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Summary:The placenta is a transitory structure indispensable for the proper development of the embryo and fetus during mammalian gestation. Like other members of the nuclear receptor family, the peroxisome proliferator-activated receptors (PPARs) are known to be involved in the physiological and pathological events occurring during the placentation. This placental involvement has been recently reviewed focusing on the early stages of placental development (implantation and invasion, etc.), mouse PPARs knockout phenotypes, and cytotrophoblast physiology. In this review, we describe the placental involvement of PPARs (e.g., fat transport and metabolism, etc.) during the late stages of gestation and in the amniotic membranes, highlighting their roles in the inflammation process (e.g., chorioamnionitis), metabolic disorders (e.g., diabetes), and parturition.
ISSN:1687-4757
1687-4765
DOI:10.1155/2008/758562