Enhancing cell-mediated immunity through dendritic cell activation: the role of Tri-GalNAc-modified PLGA-PEG nanoparticles encapsulating SR717

M. Tuberculosis fusion proteins (TP) and the STING agonist SR717 are co-encapsulated within Triantennary N-Acetylgalactosamine (Tri-GalNAc)-modified PLGA-PEG nanoparticles, denoted as TP/GPS. Following subcutaneous administration, these TP/GPS are effectively phagocytosed by dendritic cells (DCs). T...

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Bibliographic Details
Published in:Frontiers in immunology 2024-12, Vol.15
Main Authors: Gong, Yang, Jia, Hongbin, Dang, Wenrui, Zhou, Ting, He, Pu, Wang, Xiaolei, Zhu, Bingdong
Format: Article
Language:English
Subjects:
adjuvant
dendritic cells
Immunology
PLGA-PEG nanoparticles
SR717
Tri-GalNAc
tuberculosis
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Summary:M. Tuberculosis fusion proteins (TP) and the STING agonist SR717 are co-encapsulated within Triantennary N-Acetylgalactosamine (Tri-GalNAc)-modified PLGA-PEG nanoparticles, denoted as TP/GPS. Following subcutaneous administration, these TP/GPS are effectively phagocytosed by dendritic cells (DCs). The encapsulated TP and SR717 are then released, stimulating the DCs maturation and antigen presentation to T cells. This leads to the subsequent activation and differentiation of CD4 + and CD8 + T cells into memory T cells.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2024.1490003