The tape-stripping technique as a method for drug quantification in skin

Quantification of drugs within the skin is essential for topical and transdermal delivery research. Over the last two decades, horizontal sectioning, consisting of tape stripping throughout the stratum corneum, has become one of the traditional investigative techniques. Tape stripping of human strat...

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Bibliographic Details
Published in:Journal of pharmacy & pharmaceutical sciences 2008-01, Vol.11 (1), p.104-130
Main Authors: Escobar-Chávez, J J, Merino-Sanjuán, V, López-Cervantes, M, Urban-Morlan, Z, Piñón-Segundo, E, Quintanar-Guerrero, D, Ganem-Quintanar, A
Format: Article
Language:English
Subjects:
Adhesives
Administration, Cutaneous
Animals
Epidermis - chemistry
Epidermis - drug effects
Epidermis - metabolism
Humans
Pharmaceutical Preparations - administration & dosage
Pharmaceutical Preparations - analysis
Pharmaceutical Preparations - metabolism
Skin - chemistry
Skin - drug effects
Skin - metabolism
Skin Absorption - drug effects
Skin Absorption - physiology
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Summary:Quantification of drugs within the skin is essential for topical and transdermal delivery research. Over the last two decades, horizontal sectioning, consisting of tape stripping throughout the stratum corneum, has become one of the traditional investigative techniques. Tape stripping of human stratum corneum is widely used as a method for studying the kinetics and penetration depth of drugs. This paper shows the applications of the tape stripping technique to quantify drug penetration through the skin, underlining its versatile application in the area of topical and transdermal drugs.
ISSN:1482-1826
1482-1826
DOI:10.18433/j3201z