Research Progress of Estrogen Receptor in Ovarian Cancer

Objective: This review aims to provide some theoretical guidance for the precise treatment of ovarian cancer and the development of estrogen-related drugs. Mechanism: Ovarian cancer is one of the leading causes of death in gynecological cancer patients, mainly affecting middle-aged and elderly women...

Full description

Saved in:
Bibliographic Details
Published in:Clinical and experimental obstetrics & gynecology 2023-09, Vol.50 (9), p.199
Main Authors: Zhang, Mengchen, Xu, Haohui, Zhang, Yixin, Li, Zhanfei, Meng, Wenqiang, Xia, Jiayi, Lei, Wentao, Meng, Kai, Guo, Yan
Format: Article
Language:English
Subjects:
estrogen
estrogen receptor
ovarian cancer
precise treatment
receptor modulators
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective: This review aims to provide some theoretical guidance for the precise treatment of ovarian cancer and the development of estrogen-related drugs. Mechanism: Ovarian cancer is one of the leading causes of death in gynecological cancer patients, mainly affecting middle-aged and elderly women. It has the characteristics of hidden location, strong heterogeneity and lack of specific symptoms in the early stage. Numerous studies have shown that estrogen receptor (ER) plays an important role in different types of cancer, including ovarian cancer. Accordingly, the study of ER signaling pathways and related regulatory factors in ovarian cancer cells should help us understand the pathogenesis of ovarian cancer. Findings in Brief: The expression of estrogen receptor subtypes is related to ovarian cancer gene and leads to ovarian cancer. Estrogen receptor modulators appear to be an important factor in the prognosis of patients with ovarian cancer after hormone therapy. Conclusions: This review summarizes the regulatory mechanism of ER in the occurrence and development of ovarian cancer and outlines the specific role of estrogen receptor modulators (SERMs) in the treatment and prevention of ovarian cancer.
ISSN:0390-6663
2709-0094
DOI:10.31083/j.ceog5009199