The Role of Vitamin D on the Wound Healing Process: A Case Series

Vitamin D is an essential steroid hormone that consists of two forms, namely vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol), which can be obtained from exposure to sunlight, synthesis of vitamin D in the skin, food and dietary supplements. Prevalence of vitamin D deficiency in several...

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Bibliographic Details
Published in:International medical case reports journal 2023-04, Vol.16, p.227-232
Main Authors: Siregar, Fitri Dona, Hidayat, Wahyu
Format: Article
Language:English
Subjects:
Alfacalcidol
Apoptosis
Calcifediol
Cancer
Care and treatment
Case reports
Case Series
Dietary supplements
Drug dosages
Erythema
Fruits
Granulomas
Growth factors
immune system
Laboratories
Mineral water
mouth ulceration
Oral diseases
Pain
Patients
role
Skin
Steroid hormones
Steroids
Ulcers
Vitamin D
Vitamin deficiency
Wound healing
Wounds and injuries
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Summary:Vitamin D is an essential steroid hormone that consists of two forms, namely vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol), which can be obtained from exposure to sunlight, synthesis of vitamin D in the skin, food and dietary supplements. Prevalence of vitamin D deficiency in several countries including Indonesia is still high, while the role of vitamin D is very important including accelerating the wound healing process, increasing the immune system, anti-inflammatory, and anti-bacterial. This case report aims to find out the role of vitamin D in the wound-healing process in the oral mucosa. Two men went to the Oral Disease Clinic with complaints of canker sores on the oral mucosa for more than a month accompanied by pain. Intra-oral condition in the first patient showed multiple ulcers with yellowish white base surrounded by erythematous areas, well-defined, irregular with a size of 1.5 × 1 cm and 1 × 0.5 cm on the right and left buccal mucosa, while intra-oral in the second patient, a single ulcer with a base was found yellowish colour surrounded by erythematous area, oval measuring 3x1 cm, clearly demarcated with induration. Laboratory examination of vitamin D in both patients showed decreased levels of vitamin D with values of 28.7 and 9.8 ng/mL. Vitamin D supplementation has shown effectiveness in wound-healing processes in the oral mucosa.
ISSN:1179-142X
1179-142X
DOI:10.2147/IMCRJ.S402005