Silver Nanoparticles Coated Poly(L-Lactide) Electrospun Membrane for Implant Associated Infections Prevention

Bacterial infection has been a critic problem for implant infections. Poly(L-lactide) (PLLA) membrane has great potential for Guided bone regeneration (GBR), however, PLLA lack antibacterial property and thus may face bacterial infections. In this work, a mussel inspired method was used to treat PLL...

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Bibliographic Details
Published in:Frontiers in pharmacology 2020-04, Vol.11, p.431-431
Main Authors: Wang, Jiaolong, Zhan, Lilin, Zhang, Xianhua, Wu, Runfa, Liao, Lan, Wei, Junchao
Format: Article
Language:English
Subjects:
Ag nanoparticles
antibacterial
electrospun
guided bone regeneration
Pharmacology
poly(L-lactide)
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Summary:Bacterial infection has been a critic problem for implant infections. Poly(L-lactide) (PLLA) membrane has great potential for Guided bone regeneration (GBR), however, PLLA lack antibacterial property and thus may face bacterial infections. In this work, a mussel inspired method was used to treat PLLA membrane with dopamine and formed polydopamine (PDA) coated PLLA (PLLA@PDA), and then silver Nanoparticles (AgNPs) was immobilized on the surface of PLLA the reduction effect of PDA. The XPS results showed that the silver element contents may be tuned from 1.6% to 15.4%. The AgNPs coated PLLA (PLLA@Ag) showed good antibacterial property (98.3% bactericidal efficiency may be obtained) and good biocompatibility, implying that the PLLA@Ag membrane have potential application as antibacterial GBR membrane, which may enhance the application of PLLA.
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2020.00431