Efficacy of opioids versus placebo in chronic pain: a systematic review and meta-analysis of enriched enrollment randomized withdrawal trials

Opioids have been used for millennia for the treatment of pain. However, the long-term efficacy of opioids to treat chronic non-cancer pain continues to be debated. To evaluate opioids' efficacy in chronic non-cancer pain, we performed a meta-analysis of published clinical trials for μ-opioid r...

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Bibliographic Details
Published in:Journal of pain research 2018-01, Vol.11, p.923-934
Main Authors: Meske, Diana S, Lawal, Oluwadolapo D, Elder, Harrison, Langberg, Valerie, Paillard, Florence, Katz, Nathaniel
Format: Article
Language:English
Subjects:
Analysis
Arthritis
Back pain
Bias
Biological products
Cancer
Cancer pain
Care and treatment
Chronic illnesses
Chronic pain
Drug approval
EERW trials
Evidence-based medicine
FDA approval
long-term efficacy
Medical research
meta-analysis
Narcotics
non-cancer pain
opioid analgesics
Opioids
Original Research
Pain management
Patients
Product development
Quality of life
Retirement benefits
Studies
Systematic review
Tapentadol
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Description
Summary:Opioids have been used for millennia for the treatment of pain. However, the long-term efficacy of opioids to treat chronic non-cancer pain continues to be debated. To evaluate opioids' efficacy in chronic non-cancer pain, we performed a meta-analysis of published clinical trials for μ-opioid receptor agonists performed for US Food and Drug Administration approval. MEDLINE and Cochrane trial register were searched for enriched enrollment randomized withdrawal studies (before June 2016). Selection criteria included: adults, ≥10 subjects per arm, any chronic pain condition, double-blind treatment period lasting ≥12 weeks, and all μ-agonist opioids approved in the USA. Fifteen studies met criteria. Opioid efficacy was statistically significant (
ISSN:1178-7090
1178-7090
DOI:10.2147/JPR.S160255