Potential protective role of interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) in COVID-19

The COVID-19 pandemic has prompted a quest to understand why certain individuals remain uninfected or asymptomatic despite repetitive exposure to SARS-CoV-2. Here, we focused on six exposed females residing with their symptomatic and reinfected SARS-CoV-2 PCR-positive COVID-19 partners. Peripheral b...

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Bibliographic Details
Published in:Frontiers in cellular and infection microbiology 2024-11, Vol.14, p.1464581
Main Authors: de Castro, Mateus V, Cariste, Leonardo M, Almeida, Rafael R, Sasahara, Greyce L, Silva, Monize V R, Soares, Flávia B, Coria, Vivian R, Naslavsky, Michel S, Santos, Keity S, Cunha-Neto, Edecio, Kalil, Jorge, Zatz, Mayana
Format: Article
Language:English
Subjects:
Adult
Cellular and Infection Microbiology
COVID-19
COVID-19 - immunology
Female
Humans
IFIT3
innate immunity
Interferons - genetics
Interferons - immunology
Interferons - metabolism
Leukocytes, Mononuclear - immunology
Leukocytes, Mononuclear - metabolism
Male
Middle Aged
Poly I-C
protection
SARS-CoV-2
SARS-CoV-2 - genetics
SARS-CoV-2 - immunology
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Summary:The COVID-19 pandemic has prompted a quest to understand why certain individuals remain uninfected or asymptomatic despite repetitive exposure to SARS-CoV-2. Here, we focused on six exposed females residing with their symptomatic and reinfected SARS-CoV-2 PCR-positive COVID-19 partners. Peripheral blood mononuclear cell samples from couples were analysed for poly (I:C)-induced mRNA expression of type I/III interferons and interferon-stimulated genes (ISGs). Remarkably, we found a significant upregulation of the ISG interferon-inducible protein with tetrapeptide repeats 3 (IFIT3) gene exclusively in exposed uninfected or asymptomatic females, suggesting a potential role in protective immunity against symptomatic COVID-19.
ISSN:2235-2988
2235-2988
DOI:10.3389/fcimb.2024.1464581