Associations between NIH Toolbox Cognition Battery and in vivo brain amyloid and tau pathology in non‐demented older adults

Introduction The National Institutes of Health (NIH) Toolbox Cognition Battery (NIHTB‐CB) was developed to be a common assessment metric across a broad array of research studies. We investigated associations between NIHTB‐CB and brain amyloid and tau deposition in cognitively unimpaired older adults...

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Published in:Alzheimer's & dementia : diagnosis, assessment & disease monitoring assessment & disease monitoring, 2020, Vol.12 (1), p.e12018-n/a
Main Authors: Snitz, Beth E., Tudorascu, Dana L., Yu, Zheming, Campbell, Elizabeth, Lopresti, Brian J., Laymon, Charles M., Minhas, Davneet S., Nadkarni, Neelesh K., Aizenstein, Howard J., Klunk, William E., Weintraub, Sandra, Gershon, Richard C., Cohen, Ann D.
Format: Article
Language:English
Subjects:
Aging
Alzheimer's disease
Biomarkers
cognition
Cognition & reasoning
Cognitive & Behavioral Assessment
Cognitive ability
Dementia
Executive function
Heart
Magnetic resonance imaging
Medical imaging
Memory
neuropsychology
Older people
Scanners
Semantics
Standard scores
Validation studies
Validity
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Summary:Introduction The National Institutes of Health (NIH) Toolbox Cognition Battery (NIHTB‐CB) was developed to be a common assessment metric across a broad array of research studies. We investigated associations between NIHTB‐CB and brain amyloid and tau deposition in cognitively unimpaired older adults. Methods One hundred eighteen community‐based volunteers completed magnetic resonance imaging (MRI), Pittsburgh compound B (PiB)‐PET (positron emission tomography) and AV‐1451‐PET neuroimaging, a neuropsychological evaluation, NIHTB‐CB, and the Clinical Dementia Rating (CDR) scale. Demographically adjusted regression models evaluated cognition–biomarker associations; standardized effect sizes allowed comparison of association strength across measures. Results No NIHTB‐CB measures were associated with amyloid deposition. NIHTB‐CB measures of fluid cognition, including Pattern Comparison Processing Speed, Dimensional Change Card Sort, and Fluid Cognition Composite, were associated with tau deposition in higher Braak regions. Pattern Comparison Processing Speed was the most robust association with sensitivity analyses. Discussion NIHTB‐CB tasks of processing speed and executive functions may be sensitive to pathologic tau deposition on imaging in normal aging.
ISSN:2352-8729
2352-8729
DOI:10.1002/dad2.12018