A double-layer hydrogel based on alginate-carboxymethyl cellulose and synthetic polymer as sustained drug delivery system

A new double-layer, pH-sensitive, composite hydrogel sustained-release system based on polysaccharides and synthetic polymers with combined functions of different inner/outer hydrogels was prepared. The polysaccharides inner core based on sodium alginate (SA) and carboxymethyl cellulose (CMC), was f...

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Bibliographic Details
Published in:Scientific reports 2021-04, Vol.11 (1), p.9142-9142, Article 9142
Main Authors: Hu, Yan, Hu, Sheng, Zhang, Shangwen, Dong, Siyi, Hu, Jie, Kang, Li, Yang, Xinzhou
Format: Article
Language:English
Subjects:
631/154
639/301
Alginic acid
Carboxymethylcellulose
Cellulose
Controlled release
Drug delivery
Functional foods & nutraceuticals
Humanities and Social Sciences
Hydrogels
Indomethacin
multidisciplinary
pH effects
Polymers
Polysaccharides
Saccharides
Science
Science (multidisciplinary)
Sodium alginate
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Summary:A new double-layer, pH-sensitive, composite hydrogel sustained-release system based on polysaccharides and synthetic polymers with combined functions of different inner/outer hydrogels was prepared. The polysaccharides inner core based on sodium alginate (SA) and carboxymethyl cellulose (CMC), was formed by physical crosslinking with pH-sensitive property. The synthetic polymer out-layer with enhanced stability was introduced by chemical crosslinking to eliminate the expansion of inner core and the diffusion of inner content. The physicochemical structure of the double-layer hydrogels was characterized. The drug-release results demonstrated that the sustained-release effect of the hydrogels for different model drugs could be regulated by changing the composition or thickness of the hydrogel layer. The significant sustained-release effect for BSA and indomethacin indicated that the bilayer hydrogel can be developed into a novel sustained delivery system for bioactive substance or drugs with potential applications in drugs and functional foods.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-88503-1