The Role of AKR1B10 in Physiology and Pathophysiology

AKR1B10 is a human nicotinamide adenine dinucleotide phosphate (NADPH)-dependent reductase belonging to the aldo-keto reductase (AKR) 1B subfamily. It catalyzes the reduction of aldehydes, some ketones and quinones, and interacts with acetyl-CoA carboxylase and heat shock protein 90α. The enzyme is...

Full description

Saved in:
Bibliographic Details
Published in:Metabolites 2021-05, Vol.11 (6), p.332
Main Authors: Endo, Satoshi, Matsunaga, Toshiyuki, Nishinaka, Toru
Format: Article
Language:English
Subjects:
Acetyl-CoA carboxylase
AKR1B10
Aldehydes
Aldo-keto reductase
aldo-keto reductases
Antitumor agents
biomarkers
Cancer
Chemoresistance
Dehydrogenases
Epithelial cells
Fatty liver
Gastrointestinal tract
Gene regulation
Genes
Heat shock proteins
Inflammatory bowel diseases
Intestine
Kinases
Liver diseases
Localization
NADPH-diaphorase
Pathogenesis
Physiology
Proteins
Quinones
Review
Signal transduction
Skin diseases
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:AKR1B10 is a human nicotinamide adenine dinucleotide phosphate (NADPH)-dependent reductase belonging to the aldo-keto reductase (AKR) 1B subfamily. It catalyzes the reduction of aldehydes, some ketones and quinones, and interacts with acetyl-CoA carboxylase and heat shock protein 90α. The enzyme is highly expressed in epithelial cells of the stomach and intestine, but down-regulated in gastrointestinal cancers and inflammatory bowel diseases. In contrast, AKR1B10 expression is low in other tissues, where the enzyme is upregulated in cancers, as well as in non-alcoholic fatty liver disease and several skin diseases. In addition, the enzyme’s expression is elevated in cancer cells resistant to clinical anti-cancer drugs. Thus, growing evidence supports AKR1B10 as a potential target for diagnosing and treating these diseases. Herein, we reviewed the literature on the roles of AKR1B10 in a healthy gastrointestinal tract, the development and progression of cancers and acquired chemoresistance, in addition to its gene regulation, functions, and inhibitors.
ISSN:2218-1989
2218-1989
DOI:10.3390/metabo11060332