Time to positivity of Klebsiella pneumoniae in blood cultures as prognostic marker in patients with intra-abdominal infection: A retrospective study

• Published in: Virulence 2024-12, Vol.15 (1), p.2329397-2329397
• Main Authors: Yang, Yong-Ye, Tsai, I-Ting, Lai, Chung-Hsu, Chen, Chih-Ping, Chen, Chia-Chi, Hsu, Yin-Chou
• Format: Article
• Language: English
• Subjects: Adult; bacteraemia; Bacteremia - diagnosis; Blood Culture; Humans; intra-abdominal infections; Intraabdominal Infections - diagnosis; Klebsiella Infections - diagnosis; Klebsiella pneumoniae; Prognosis; Retrospective Studies; time to positivity
• ISSN: 2150-5594; 2150-5608
• DOI: 10.1080/21505594.2024.2329397

is a common causative pathogen of intra-abdominal infection with concomitant bacteraemia, leading to a significant mortality risk. The time to positivity (TTP) of blood culture is postulated to be a prognostic factor in bacteraemia caused by other species. Therefore, this study aimed to investigate the prognostic value of TTP in these patients. The single-centred, retrospective, observational cohort study was conducted between 1 July 2016 and 30 June 2021. All adult emergency department patients with diagnosis of intra-abdominal infection and underwent blood culture collection which yield during this period were enrolled. A total of 196 patients were included in the study. The overall 30-day mortality rate was 12.2% (24/196), and the median TTP of the studied cohort was 12.3 h (10.5-15.8 h). TTP revealed a moderate 30-day mortality discriminative ability (area under the curve 0.73,  12 h,  = 109), patients in the early TTP (≤12 h,  = 87) group had a significantly higher risk of 30-day morality (21.8% vs. 4.6%,