Serum 25-Hydroxyvitamin D and the risk of mortality in adult patients with Sepsis: a meta-analysis

• Published in: BMC infectious diseases 2020-03, Vol.20 (1), p.189-189, Article 189
• Main Authors: Li, Yuye, Ding, Shifang
• Format: Article
• Language: English
• Subjects: 25-Hydroxyvitamin D; Adult; Aged; Calciferol; Clinical medicine; Complications and side effects; Diagnostic systems; Female; Follow-Up Studies; Handbooks; Homeostasis; Humans; Immunoassay; Incidence; Infection; Infectious diseases; Inflammatory response; Male; Medical research; Meta-analysis; Metabolism; Middle Aged; Mortality; Multivariate analysis; Patient outcomes; Prognosis; Risk; Risk factors; Sepsis; Sepsis - blood; Sepsis - epidemiology; Sepsis - mortality; Studies; Subgroups; Systemic inflammatory response syndrome; Vitamin D; Vitamin D - analogs & derivatives; Vitamin D - blood; Vitamin D deficiency; Vitamin D Deficiency - blood; Vitamin D Deficiency - epidemiology; Vitamin deficiency
• ISSN: 1471-2334; 1471-2334
• DOI: 10.1186/s12879-020-4879-1

Vitamin D deficiency has been related to the risk of sepsis. However, previous studies showed inconsistent results regarding the association between serum 25-hydroxyvitamin D (25 (OH) D) and mortality risk in septic patients. We aimed to evaluate the relationship between serum 25 (OH) D at admission and mortality risk in adult patients in a meta-analysis. Follow-up studies that provided data of multivariate adjusted relative risk (RR) between serum 25 (OH) D and mortality risk in septic patients were retrieved via systematic search of PubMed and Embase databases. A random effect model was used to pool the results. Eight studies with 1736 patients were included. Results of overall meta-analysis showed that lower 25 (OH) D at admission was independently associated with increased risk or mortality (adjusted RR: 1.93, p