GPX2 Gene Affects Feed Efficiency of Pigs by Inhibiting Fat Deposition and Promoting Muscle Development

GPX2 has been recognized as a potential candidate gene for feed efficiency in pigs. This article aimed to elucidate polymorphism of GPX2 associated with feed efficiency and its related molecular mechanism. In this study, seven single nucleotide polymorphisms (SNP) of GPX2 were found among 383 Duroc...

Full description

Saved in:
Bibliographic Details
Published in:Animals (Basel) 2022-12, Vol.12 (24), p.3528
Main Authors: Pu, Lei, Luo, Yunyan, Wen, Zuochen, Dai, Yuxin, Zheng, Chunting, Zhu, Xueli, Qin, Lei, Zhang, Chunguang, Liang, Hong, Zhang, Jianbin, Guo, Liang, Wang, Lixian
Format: Article
Language:English
Subjects:
Adenoviruses
adipocyte
Animals
backfat
Cell culture
Cell differentiation
Cell growth
Cell proliferation
Conversion ratio
Deposition
Differentiation
Efficiency
Feed conversion
Feed efficiency
Feeds
Gene expression
Gene polymorphism
Glutathione peroxidase
GPX2
GPX2 gene
Haplotypes
Insulin resistance
Lipids
molecular mechanism
Muscles
Nucleotides
Nutrients
Peroxidase
Polymorphism
Recording equipment
Regression analysis
Single-nucleotide polymorphism
SNP
Weaning
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:GPX2 has been recognized as a potential candidate gene for feed efficiency in pigs. This article aimed to elucidate polymorphism of GPX2 associated with feed efficiency and its related molecular mechanism. In this study, seven single nucleotide polymorphisms (SNP) of GPX2 were found among 383 Duroc pigs. In addition, seven SNPs and ALGA0043483 (PorcineSNP60 BeadChip data in 600 Duroc pigs), which are near the GPX2 gene, were identified in one haplotypes block. Furthermore, associated studies showed that the genotype of GPX2 has significant association with weaning weight and 100 kg BF in Duroc pigs. In addition, the AG had no effect when the backfat became thinner, and the FCR and RFI traits had a tendency to decrease in the G3 + TT combination genotype, accompanied by an increase of GPX2 expression in backfat and muscle tissues. At the cellular level, the adipocyte proliferation and ability of adipogenic differentiation were reduced, and the lipid degradation increased in 3T3-L1 when there was overexpression of GPX2. In contrast, overexpression of the GPX2 gene can promote the muscle cell proliferation and myogenic differentiation in C2C12 cells. In other words, GPX2 has the effect of reducing fat deposition and promoting muscle development, and it is a candidate gene for backfat and feed efficiency.
ISSN:2076-2615
2076-2615
DOI:10.3390/ani12243528