Factors associated with the SARS-CoV-2 immunoglobulin-G titer levels in convalescent whole-blood donors: a Chinese cross-sectional study

Blood transfusions from convalescent Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infected patients could be used to treat patients with severe infections or immunocompromised patients. However, it is necessary to select the optimal donors to maximize the utilization of resources. In...

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Bibliographic Details
Published in:Scientific reports 2024-03, Vol.14 (1), p.6072-6072, Article 6072
Main Authors: Tan, Donglin, Du, Xinman, Tang, Jingyun, Liu, Humin, Li, Meng, Kang, Jianxun, Li, Xiaochun, Li, Ying, Luo, Yue, Wang, Qing, Gu, Xiaobo, Zhao, Zonghan, Fu, Xuemei, Chen, Xue
Format: Article
Language:English
Subjects:
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Antibodies
Antibodies, Viral
Blood & organ donations
Blood Donors
Blood transfusion
Blood transfusions
Body mass index
China
Coronaviruses
COVID-19
COVID-19 Serotherapy
Cross-Sectional Studies
Exercise
Female
Females
Humanities and Social Sciences
Humans
Immunization, Passive
Immunocompromised hosts
Immunoglobulin G
Immunoglobulins
Infections
Male
multidisciplinary
Pandemics
Physical fitness
Plasma
SARS-CoV-2
Science
Science (multidisciplinary)
Severe acute respiratory syndrome coronavirus 2
Smoking
Tobacco smoking
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Summary:Blood transfusions from convalescent Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infected patients could be used to treat patients with severe infections or immunocompromised patients. However, it is necessary to select the optimal donors to maximize the utilization of resources. In this study, we investigated the associations among body mass index (BMI), tobacco smoking, exercise frequency and duration, and alcohol consumption with the SARS-CoV-2 immunoglobulin-G (IgG) antibody titer levels with in the Chinese convalescent blood donor population. Here we show that BMI, smoking habits, and exercise frequency appear to be predictive factors for IgG levels in convalescent male blood donors. However, these variables were not observed as predictive of IgG levels in female convalescent blood donors. The findings could be used to optimize the screening for potential blood donors to treat immunocompromised or severely ill COVID-19 patients.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-56462-y