Antioxidant and radical scavenging activities of some norcantharidin and bridged perhydroisoindole derivatives

A series of norcantharidin and bridged perhydroisoindole derivatives were evaluated for their antioxidant and radical scavenging activities. Different in vitro methodologies such as total reducing power, 1,1-diphenyl-2- picrylhydrazil (DPPH?) free radical scavenging, superoxide anion radical scaveng...

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Bibliographic Details
Published in:Journal of the Serbian Chemical Society 2013, Vol.78 (1), p.15-25
Main Authors: Peksel, Aysegul, Celik, Cumali, Ocal, Nuket, Yanardag, Refiye
Format: Article
Language:English
Subjects:
Anions
Antioxidants
bridged perhydroisoindole
Chelation
Free radicals
In vitro methods and tests
norcantharidin
Oxidation
reducing power
Scavenging
superoxide anion radical
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Summary:A series of norcantharidin and bridged perhydroisoindole derivatives were evaluated for their antioxidant and radical scavenging activities. Different in vitro methodologies such as total reducing power, 1,1-diphenyl-2- picrylhydrazil (DPPH?) free radical scavenging, superoxide anion radical scavenging and metal chelating activities were used. Among 11 compounds tested, 7 compounds showed potent reducing power activity and 8 compounds showed potent superoxide anion radical scavenging activity. All the tested compounds exhibited potent free radical scavenging ability. The results showed that the synthesized compounds had effective antioxidant power. nema
ISSN:0352-5139
1820-7421
DOI:10.2298/JSC120123036P