Multidrug-resistant Mycobacterium tuberculosis, Bangui, Central African Republic

We investigated multidrug-resistant (MDR) Mycobacterium tuberculosis strains in Bangui, Central African Republic. We found 39.6% with the same spoligotype and synonymous single nucleotide polymorphism in the mutT1 gene. However, strains had different rpoB mutations responsible for rifampin resistanc...

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Bibliographic Details
Published in:Emerging infectious diseases 2006-09, Vol.12 (9), p.1454-1456
Main Authors: Nouvel, Laurent X, Kassa-Kelembho, Eric, Dos Vultos, Tiago, Zandanga, Germain, Rauzier, Jean, Lafoz, Carmen, Martin, Carlos, Blazquez, Jesus, Talarmin, Antoine, Gicquel, Brigitte
Format: Article
Language:English
Subjects:
Antibiotic resistance
Antitubercular Agents - pharmacology
Bacterial Proteins - genetics
Care and treatment
Central African Republic
Central African Republic - epidemiology
Diseases
Dispatch
DNA Repair
DNA-Directed RNA Polymerases
Genetic aspects
Health aspects
HIV patients
Humans
Molecular epidemiology
Mutation
Mycobacterium tuberculosis
Mycobacterium tuberculosis - classification
Mycobacterium tuberculosis - drug effects
Mycobacterium tuberculosis - genetics
Mycobacterium tuberculosis - isolation & purification
Oligonucleotides - analysis
Polymorphism, Single Nucleotide
Tuberculosis
Tuberculosis, Multidrug-Resistant - epidemiology
Tuberculosis, Multidrug-Resistant - microbiology
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Summary:We investigated multidrug-resistant (MDR) Mycobacterium tuberculosis strains in Bangui, Central African Republic. We found 39.6% with the same spoligotype and synonymous single nucleotide polymorphism in the mutT1 gene. However, strains had different rpoB mutations responsible for rifampin resistance. MDR strains in Bangui may emerge preferentially from a single, MDR-prone family.
ISSN:1080-6040
1080-6059
DOI:10.3201/eid1209.060361