Flt3 Regulation in the Mononuclear Phagocyte System Promotes Ocular Neovascularization

Fms-like tyrosine kinase 3 (Flt3), a tyrosine kinase receptor expressed in CD34+ hematopoietic stem/progenitor cells, is important for both normal myeloid and lymphoid differentiation. It has been implicated in mice and humans for potential multilineage differentiation. We found that mice deficient...

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Bibliographic Details
Published in:Journal of ophthalmology 2018-01, Vol.2018 (2018), p.1-14
Main Authors: Xie, Bing, Shen, Xi, Shen, Jikui, Cai, Yujuan, Demetriades, Anna M., Zhu, Yanji, Zhong, Yisheng, Gao, Yushuo, Lu, Qing
Format: Article
Language:English
Subjects:
Analysis
Angiogenesis
Antibodies
Ischemia
Kinases
Laboratories
Lasers
Lectins
Macular degeneration
Microscopy
Neovascularization
Retina
Retinal detachment
Transgenic animals
Tyrosine
Vascular endothelial growth factor
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Summary:Fms-like tyrosine kinase 3 (Flt3), a tyrosine kinase receptor expressed in CD34+ hematopoietic stem/progenitor cells, is important for both normal myeloid and lymphoid differentiation. It has been implicated in mice and humans for potential multilineage differentiation. We found that mice deficient in Flt3 or mice that received an Flt3 inhibitor (AC220) showed significantly reduced areas of ischemia-induced retinal neovascularization (RNV) and laser-induced choroidal NV (CNV) (P
ISSN:2090-004X
2090-0058
DOI:10.1155/2018/2518568