The Natural History of Peyronie's Disease

Peyronie's disease (PD), a fibrotic disorder of the tunica albuginea fully described in 1793 by French physician Francois de la Peyronie, is characterized by pain, plaque formation, penile deformity, and ultimately sexual function decline. The epidemiological data on PD vary considerably across...

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Bibliographic Details
Published in:The World Journal of Men's Health 2021-07, Vol.39 (3), p.399-405
Main Authors: Di Maida, Fabrizio, Cito, Gianmartin, Lambertini, Luca, Valastro, Francesca, Morelli, Girolamo, Mari, Andrea, Carini, Marco, Minervini, Andrea, Cocci, Andrea
Format: Article
Language:English
Subjects:
Angiogenesis
Collagen
Connective tissue diseases
Dendritic cells
Fibroblasts
Growth factors
Hypoxia
Inflammation
Natural history
Pain
Pathogenesis
Pathophysiology
Patients
penile diseases
penile erection
penile induration
Penis
Review
Sexual intercourse
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Summary:Peyronie's disease (PD), a fibrotic disorder of the tunica albuginea fully described in 1793 by French physician Francois de la Peyronie, is characterized by pain, plaque formation, penile deformity, and ultimately sexual function decline. The epidemiological data on PD vary considerably across previous studies, with recent evidence reporting a prevalence of up to 9%. PD is generally divided into two different phases: active or acute and stable or chronic. Plaque formation generally occurs during the acute phase, while during chronic phase pain usually tends to complete resolution and penile deformity stabilizes. PD's pathophysiology is still subject of great discussion. Tunical mechanical stress and microvascular trauma are major contributory factors. However, better understanding of the molecular pathophysiology of this condition remains paramount towards an in-depth comprehension of the disorder and the development of newer and more effective disease-targeted interventions. In this review we provide a detailed overview of natural history of PD, specifically focusing on clinical manifestations and the underlying molecular regulation patterns.
ISSN:2287-4208
2287-4690
DOI:10.5534/wjmh.200065