Local effect of simvastatin combined with different osteoconductive biomaterials and collagen sponge on new bone formation in critical defects in rat calvaria

Abstract Purpose To evaluate the local effect of simvastatin (SVT) combined with deproteinized bovine bone (DBB) with hydroxyapatite/β-tricalcium phosphate biphasic ceramics (HA/TCP) and with collagen sponge (CS) on bone repair in critical size defects (CSDs) in rat calvaria. Methods Forty-two 5-mm...

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Published in:Acta cirúrgica brasileira 2020-01, Vol.35 (1)
Main Authors: Sousa, Dircilei Nascimento de, Roriz, Virgílio Moreira, Oliveira, Guilherme José Pimentel Lopes de, Duarte, Wagner Rodrigues, Pinto, Leonardo Nogueira de Miranda Pereira, Vianna, Leonora Maciel de Souza, Carneiro, Fabiana Pirani, Ferreira, Vania Maria Moraes
Format: Article
Language:English
Subjects:
Biocompatible Materials
Bone Regeneration
Rats
Simvastatin
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Summary:Abstract Purpose To evaluate the local effect of simvastatin (SVT) combined with deproteinized bovine bone (DBB) with hydroxyapatite/β-tricalcium phosphate biphasic ceramics (HA/TCP) and with collagen sponge (CS) on bone repair in critical size defects (CSDs) in rat calvaria. Methods Forty-two 5-mm diameter CSDs were made bilaterally in the calvaria of 18 rats. The animals were allocated according to the type of biomaterial and associations used to fill the CSD. After 8 weeks, the animals were euthanized, and their calvaria were evaluated for repaired tissue composition using histologic and histometric analyses. Results In the histometric analysis, the use of SVT showed to increase bone formation in the CSDs when combined with all the bone substitutes tested in this study (p
ISSN:0102-8650
1678-2674
DOI:10.1590/s0102-865020200010000002