Histone lactylation bridges metabolic reprogramming and epigenetic rewiring in driving carcinogenesis: Oncometabolite fuels oncogenic transcription

Heightened lactate production in cancer cells has been linked to various cellular mechanisms such as angiogenesis, hypoxia, macrophage polarisation and T‐cell dysfunction. The lactate‐induced lactylation of histone lysine residues is noteworthy, as it functions as an epigenetic modification that dir...

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Published in:Clinical and translational medicine 2024-03, Vol.14 (3), p.e1614-n/a
Main Authors: Zhang, Yu, Song, Hang, Li, Meili, Lu, Peirong
Format: Article
Language:English
Subjects:
Adenosine
Breast cancer
cancer
Dehydrogenases
Enzymes
Epigenetics
Glucose
histone lactylation
Kinases
Medical prognosis
metabolic reprogramming
Metabolism
Metabolites
Metastasis
Phosphorylation
Proteins
Signal transduction
Tissues
Tumors
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Summary:Heightened lactate production in cancer cells has been linked to various cellular mechanisms such as angiogenesis, hypoxia, macrophage polarisation and T‐cell dysfunction. The lactate‐induced lactylation of histone lysine residues is noteworthy, as it functions as an epigenetic modification that directly augments gene transcription from chromatin. This epigenetic modification originating from lactate effectively fosters a reliance on transcription, thereby expediting tumour progression and development. Herein, this review explores the correlation between histone lactylation and cancer characteristics, revealing histone lactylation as an innovative epigenetic process that enhances the vulnerability of cells to malignancy. Moreover, it is imperative to acknowledge the paramount importance of acknowledging innovative therapeutic methodologies for proficiently managing cancer by precisely targeting lactate signalling. This comprehensive review illuminates a crucial yet inadequately investigated aspect of histone lactylation, providing valuable insights into its clinical ramifications and prospective therapeutic interventions centred on lactylation. The lactate‐induced lactylation of histone lysine residues bridges the metabolic reprogramming and epigenetic rewiring. Histone lactylation fuels oncogene overexpression, expediting tumour progression and development. Targeting lactate signalling exhibits with therapeutic efficacy in diversified cancers.
ISSN:2001-1326
2001-1326
DOI:10.1002/ctm2.1614