Loading…

Differences in clinicopathologic features and subtype distribution of invasive breast cancer between women older and younger than 40 years

Objectives: We investigated and compared clinicopathologic features and subtype distribution of invasive breast cancer among women

Saved in:

Bibliographic Details
Published in:	Fujita Medical Journal 2019, Vol.5(4), pp.92-97
Main Authors:	Ushimado, Kaori, Kobayashi, Naomi, Hikichi, Masahiro, Tsukamoto, Tetsuya, Kuroda, Makoto, Utsumi, Toshiaki
Format:	Article
Language:	English
Subjects:	Breast cancer Clinicopathologic characteristics Original Subtype Young woman
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

cited_by
cites
container_end_page	97
container_issue	4
container_start_page	92
container_title	Fujita Medical Journal
container_volume	5
creator	Ushimado, Kaori Kobayashi, Naomi Hikichi, Masahiro Tsukamoto, Tetsuya Kuroda, Makoto Utsumi, Toshiaki
description	Objectives: We investigated and compared clinicopathologic features and subtype distribution of invasive breast cancer among women
doi_str_mv	10.20407/fmj.2019-001
format	article
fullrecord	<record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_d68c842feaba4345be31d2f316cfdbf9</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_d68c842feaba4345be31d2f316cfdbf9</doaj_id><sourcerecordid>2625267168</sourcerecordid><originalsourceid>FETCH-LOGICAL-d4698-f55ce932e5b1da7083a4a99097f28fdefef1d9275e6ec5c893dfa60f7529e6213</originalsourceid><addsrcrecordid>eNpVkk2PFCEQhjtG427WPXo1HL2MAt3QzcVo1q9NNvGiZ1INRQ-THhiBns38BX-1jLM7cQ_Am6q3ngpQTfOa0XecdrR_77abqphaUcqeNZecDWrVcyGen3XXXzTXOW8opZx1lEv2srloBWNMUHXZ_PnsncOEwWAmPhAz--BN3EFZxzlO3hCHUJZUsxAsyctYDjsk1ueS_LgUHwOJrlbuIfs9kjEh5EIMVGAiI5Z7xEDu47bucbY1dsQc4hKmqssaAukoOSCk_Kp54WDOeP1wXjW_vn75efN9dffj2-3Np7uV7aQaVk4Ig6rlKEZmoadDCx0oRVXv-OAsOnTMKt4LlGiEGVRrHUjqesEVSs7aq-b2xLURNnqX_BbSQUfw-l8gpklDKt7MqK0czNDx-gQjdG0nRmyZ5a5l0jg7OlVZH06s3TJu0RoMJcH8BPo0E_xaT3Gvh15K3g4V8PYBkOLvBXPRW58NzjMEjEvWXHLBZc_k0frm_17nJo-fWQ0fT4ZNLjDh2fB4mzosWuiuruPI6Doy55RZQ9IY2r9d972P</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2625267168</pqid></control><display><type>article</type><title>Differences in clinicopathologic features and subtype distribution of invasive breast cancer between women older and younger than 40 years</title><source>PubMed Central</source><creator>Ushimado, Kaori ; Kobayashi, Naomi ; Hikichi, Masahiro ; Tsukamoto, Tetsuya ; Kuroda, Makoto ; Utsumi, Toshiaki</creator><creatorcontrib>Ushimado, Kaori ; Kobayashi, Naomi ; Hikichi, Masahiro ; Tsukamoto, Tetsuya ; Kuroda, Makoto ; Utsumi, Toshiaki</creatorcontrib><description>Objectives: We investigated and compared clinicopathologic features and subtype distribution of invasive breast cancer among women <40 and ≥40 years of age.Methods: We retrospectively compared clinicopathologic characteristics and subtype distribution of invasive breast cancer in women <40 and ≥40 years of age, in a cohort of 1,130 patients. Subtypes included luminal A (positive for hormone receptors [HR]—estrogen receptor [ER] and/or progesterone receptor [PR]—and negative for human epidermal growth factor receptor 2 [HER2] with low Ki67), luminal B (HER2–) (HR+/HER2–/Ki67High), luminal B (HER2+) (HR+/HER2+), HER2-overexpressing (HR–/HER2+), and triple negative (ER–/PR–/HER2–).Results: Breast cancers in younger women had unfavorable clinicopathologic characteristics, including larger tumors and more frequent node involvement. Subtypes among the 1,130 tumors were luminal A: 36.4%, luminal B (HER2–): 35.0%, luminal B (HER2+): 7.5%, HER2-overexpressing: 7.1%, and triple negative: 14.0%. The age groups significantly differed in subtype distribution (P<0.001). Luminal A subtype was more common in the older group (38.5%) than the younger group (16.2%), and luminal B (HER2–) was more common in the younger group (52.2%) than in the older group (33.2%; P<0.001).Conclusions: Breast cancers in women younger than 40 years have unfavorable clinicopathologic characteristics and are more likely to be luminal B (HER2–) and less likely to be luminal A than breast cancers in older women.</description><identifier>ISSN: 2189-7247</identifier><identifier>EISSN: 2189-7255</identifier><identifier>DOI: 10.20407/fmj.2019-001</identifier><identifier>PMID: 35111509</identifier><language>eng</language><publisher>Japan: Fujita Medical Society</publisher><subject>Breast cancer ; Clinicopathologic characteristics ; Original ; Subtype ; Young woman</subject><ispartof>Fujita Medical Journal, 2019, Vol.5(4), pp.92-97</ispartof><rights>2019 This is an Open access article distributed under the Terms of Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8766238/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8766238/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35111509$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ushimado, Kaori</creatorcontrib><creatorcontrib>Kobayashi, Naomi</creatorcontrib><creatorcontrib>Hikichi, Masahiro</creatorcontrib><creatorcontrib>Tsukamoto, Tetsuya</creatorcontrib><creatorcontrib>Kuroda, Makoto</creatorcontrib><creatorcontrib>Utsumi, Toshiaki</creatorcontrib><title>Differences in clinicopathologic features and subtype distribution of invasive breast cancer between women older and younger than 40 years</title><title>Fujita Medical Journal</title><addtitle>FMJ</addtitle><description>Objectives: We investigated and compared clinicopathologic features and subtype distribution of invasive breast cancer among women <40 and ≥40 years of age.Methods: We retrospectively compared clinicopathologic characteristics and subtype distribution of invasive breast cancer in women <40 and ≥40 years of age, in a cohort of 1,130 patients. Subtypes included luminal A (positive for hormone receptors [HR]—estrogen receptor [ER] and/or progesterone receptor [PR]—and negative for human epidermal growth factor receptor 2 [HER2] with low Ki67), luminal B (HER2–) (HR+/HER2–/Ki67High), luminal B (HER2+) (HR+/HER2+), HER2-overexpressing (HR–/HER2+), and triple negative (ER–/PR–/HER2–).Results: Breast cancers in younger women had unfavorable clinicopathologic characteristics, including larger tumors and more frequent node involvement. Subtypes among the 1,130 tumors were luminal A: 36.4%, luminal B (HER2–): 35.0%, luminal B (HER2+): 7.5%, HER2-overexpressing: 7.1%, and triple negative: 14.0%. The age groups significantly differed in subtype distribution (P<0.001). Luminal A subtype was more common in the older group (38.5%) than the younger group (16.2%), and luminal B (HER2–) was more common in the younger group (52.2%) than in the older group (33.2%; P<0.001).Conclusions: Breast cancers in women younger than 40 years have unfavorable clinicopathologic characteristics and are more likely to be luminal B (HER2–) and less likely to be luminal A than breast cancers in older women.</description><subject>Breast cancer</subject><subject>Clinicopathologic characteristics</subject><subject>Original</subject><subject>Subtype</subject><subject>Young woman</subject><issn>2189-7247</issn><issn>2189-7255</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNpVkk2PFCEQhjtG427WPXo1HL2MAt3QzcVo1q9NNvGiZ1INRQ-THhiBns38BX-1jLM7cQ_Am6q3ngpQTfOa0XecdrR_77abqphaUcqeNZecDWrVcyGen3XXXzTXOW8opZx1lEv2srloBWNMUHXZ_PnsncOEwWAmPhAz--BN3EFZxzlO3hCHUJZUsxAsyctYDjsk1ueS_LgUHwOJrlbuIfs9kjEh5EIMVGAiI5Z7xEDu47bucbY1dsQc4hKmqssaAukoOSCk_Kp54WDOeP1wXjW_vn75efN9dffj2-3Np7uV7aQaVk4Ig6rlKEZmoadDCx0oRVXv-OAsOnTMKt4LlGiEGVRrHUjqesEVSs7aq-b2xLURNnqX_BbSQUfw-l8gpklDKt7MqK0czNDx-gQjdG0nRmyZ5a5l0jg7OlVZH06s3TJu0RoMJcH8BPo0E_xaT3Gvh15K3g4V8PYBkOLvBXPRW58NzjMEjEvWXHLBZc_k0frm_17nJo-fWQ0fT4ZNLjDh2fB4mzosWuiuruPI6Doy55RZQ9IY2r9d972P</recordid><startdate>20190101</startdate><enddate>20190101</enddate><creator>Ushimado, Kaori</creator><creator>Kobayashi, Naomi</creator><creator>Hikichi, Masahiro</creator><creator>Tsukamoto, Tetsuya</creator><creator>Kuroda, Makoto</creator><creator>Utsumi, Toshiaki</creator><general>Fujita Medical Society</general><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20190101</creationdate><title>Differences in clinicopathologic features and subtype distribution of invasive breast cancer between women older and younger than 40 years</title><author>Ushimado, Kaori ; Kobayashi, Naomi ; Hikichi, Masahiro ; Tsukamoto, Tetsuya ; Kuroda, Makoto ; Utsumi, Toshiaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-d4698-f55ce932e5b1da7083a4a99097f28fdefef1d9275e6ec5c893dfa60f7529e6213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Breast cancer</topic><topic>Clinicopathologic characteristics</topic><topic>Original</topic><topic>Subtype</topic><topic>Young woman</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ushimado, Kaori</creatorcontrib><creatorcontrib>Kobayashi, Naomi</creatorcontrib><creatorcontrib>Hikichi, Masahiro</creatorcontrib><creatorcontrib>Tsukamoto, Tetsuya</creatorcontrib><creatorcontrib>Kuroda, Makoto</creatorcontrib><creatorcontrib>Utsumi, Toshiaki</creatorcontrib><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>Fujita Medical Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ushimado, Kaori</au><au>Kobayashi, Naomi</au><au>Hikichi, Masahiro</au><au>Tsukamoto, Tetsuya</au><au>Kuroda, Makoto</au><au>Utsumi, Toshiaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differences in clinicopathologic features and subtype distribution of invasive breast cancer between women older and younger than 40 years</atitle><jtitle>Fujita Medical Journal</jtitle><addtitle>FMJ</addtitle><date>2019-01-01</date><risdate>2019</risdate><volume>5</volume><issue>4</issue><spage>92</spage><epage>97</epage><pages>92-97</pages><issn>2189-7247</issn><eissn>2189-7255</eissn><abstract>Objectives: We investigated and compared clinicopathologic features and subtype distribution of invasive breast cancer among women <40 and ≥40 years of age.Methods: We retrospectively compared clinicopathologic characteristics and subtype distribution of invasive breast cancer in women <40 and ≥40 years of age, in a cohort of 1,130 patients. Subtypes included luminal A (positive for hormone receptors [HR]—estrogen receptor [ER] and/or progesterone receptor [PR]—and negative for human epidermal growth factor receptor 2 [HER2] with low Ki67), luminal B (HER2–) (HR+/HER2–/Ki67High), luminal B (HER2+) (HR+/HER2+), HER2-overexpressing (HR–/HER2+), and triple negative (ER–/PR–/HER2–).Results: Breast cancers in younger women had unfavorable clinicopathologic characteristics, including larger tumors and more frequent node involvement. Subtypes among the 1,130 tumors were luminal A: 36.4%, luminal B (HER2–): 35.0%, luminal B (HER2+): 7.5%, HER2-overexpressing: 7.1%, and triple negative: 14.0%. The age groups significantly differed in subtype distribution (P<0.001). Luminal A subtype was more common in the older group (38.5%) than the younger group (16.2%), and luminal B (HER2–) was more common in the younger group (52.2%) than in the older group (33.2%; P<0.001).Conclusions: Breast cancers in women younger than 40 years have unfavorable clinicopathologic characteristics and are more likely to be luminal B (HER2–) and less likely to be luminal A than breast cancers in older women.</abstract><cop>Japan</cop><pub>Fujita Medical Society</pub><pmid>35111509</pmid><doi>10.20407/fmj.2019-001</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record>
fulltext	fulltext
identifier	ISSN: 2189-7247
ispartof	Fujita Medical Journal, 2019, Vol.5(4), pp.92-97
issn	2189-7247 2189-7255
language	eng
recordid	cdi_doaj_primary_oai_doaj_org_article_d68c842feaba4345be31d2f316cfdbf9
source	PubMed Central
subjects	Breast cancer Clinicopathologic characteristics Original Subtype Young woman
title	Differences in clinicopathologic features and subtype distribution of invasive breast cancer between women older and younger than 40 years
url	http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T00%3A56%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Differences%20in%20clinicopathologic%20features%20and%20subtype%20distribution%20of%20invasive%20breast%20cancer%20between%20women%20older%20and%20younger%20than%2040%20years&rft.jtitle=Fujita%20Medical%20Journal&rft.au=Ushimado,%20Kaori&rft.date=2019-01-01&rft.volume=5&rft.issue=4&rft.spage=92&rft.epage=97&rft.pages=92-97&rft.issn=2189-7247&rft.eissn=2189-7255&rft_id=info:doi/10.20407/fmj.2019-001&rft_dat=%3Cproquest_doaj_%3E2625267168%3C/proquest_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-d4698-f55ce932e5b1da7083a4a99097f28fdefef1d9275e6ec5c893dfa60f7529e6213%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2625267168&rft_id=info:pmid/35111509&rfr_iscdi=true