Isolation of Various Flavonoids with TRAIL Resistance-Overcoming Activity from Blumea lacera

Eighteen compounds, including fourteen flavonoids ( - ), one steroid ( ), two fatty acids ( , ), and one nitrogen-containing compound ( ), were isolated from the methanol extract of the whole plant collected in Thailand. Compounds - and - exhibited tumor necrosis factor-related apoptosis-inducing li...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2022-12, Vol.28 (1), p.264
Main Authors: Manome, Teruhisa, Hara, Yasumasa, Ishibashi, Masami
Format: Article
Language:English
Subjects:
Adenocarcinoma
Apoptosis
Asteraceae - metabolism
Blumea lacera
Brief Report
Cancer
Cell Line, Tumor
Chromatography
Flavonoids
Flavonoids - pharmacology
Humans
Ligands
Thai plant
TNF-Related Apoptosis-Inducing Ligand - metabolism
TNF-Related Apoptosis-Inducing Ligand - pharmacology
TRAIL protein
TRAIL resistance
Tumor Necrosis Factor-alpha
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Description
Summary:Eighteen compounds, including fourteen flavonoids ( - ), one steroid ( ), two fatty acids ( , ), and one nitrogen-containing compound ( ), were isolated from the methanol extract of the whole plant collected in Thailand. Compounds - and - exhibited tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) resistance-overcoming activity. Among them, bonanzin ( ) and cirsilineol ( ) had particularly strong TRAIL resistance-overcoming activity, where the IC values against the human gastric adenocarcinoma cell line AGS in the presence of TRAIL (100 ng/mL) were 10.7 μM and 5.9 μM, respectively.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules28010264