Comprehensive Analysis of the Differential Expression and Prognostic Value of Histone Deacetylases in Glioma

Gliomas are the most common and aggressive malignancies of the central nervous system. Histone deacetylases (HDACs) are important targets in cancer treatment. They regulate complex cellular mechanisms that influence tumor biology and immunogenicity. However, little is known about the function of HDA...

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Bibliographic Details
Published in:Frontiers in cell and developmental biology 2022-03, Vol.10, p.840759
Main Authors: Li, Jinwei, Yan, Xianlei, Liang, Cong, Chen, Hongmou, Liu, Meimei, Wu, Zhikang, Zheng, Jiemin, Dang, Junsun, La, Xiaojin, Liu, Quan
Format: Article
Language:English
Subjects:
bioinformatics analysis
biomarker
Cell and Developmental Biology
CGGA, Chinese Glioma Genome Atlas
glioma
HDACs
immune infiltration
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Summary:Gliomas are the most common and aggressive malignancies of the central nervous system. Histone deacetylases (HDACs) are important targets in cancer treatment. They regulate complex cellular mechanisms that influence tumor biology and immunogenicity. However, little is known about the function of HDACs in glioma. The Oncomine, Human Protein Atlas, Gene Expression Profiling Interactive Analysis, Broad Institute Cancer Cell Line Encyclopedia, Chinese Glioma Genome Atlas, OmicShare, cBioPortal, GeneMANIA, STRING, and TIMER databases were utilized to analyze the differential expression, prognostic value, and genetic alteration of HDAC and immune cell infiltration in patients with glioma. were considerable upregulated whereas HDAC11 was significantly downregulated in cancer tissues. were significantly correlated with the clinical glioma stage. were strongly upregulated in 11 glioma cell lines. High and low mRNA levels were significantly associated with overall survival and disease-free survival in glioma. are potential useful biomarkers for predicting the survival of patients with glioma. The functions of HDACs and 50 neighboring genes were primarily related to transcriptional dysregulation in cancers and the Notch, cGMP-PKG, and thyroid hormone signaling pathways. HDAC expression was significantly correlated with the infiltration of B cells, CD4 T cells, CD8 T cells, macrophages, neutrophils, and dendritic cells in glioma. Our study indicated that HDACs are putative precision therapy targets and prognostic biomarkers of survival in glioma patients.
ISSN:2296-634X
2296-634X
DOI:10.3389/fcell.2022.840759