Prediction of Protein-Protein Interaction Sites Based on Naive Bayes Classifier

Protein functions through interactions with other proteins and biomolecules and these interactions occur on the so-called interface residues of the protein sequences. Identifying interface residues makes us better understand the biological mechanism of protein interaction. Meanwhile, information abo...

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Bibliographic Details
Published in:Biochemistry Research International 2015-01, Vol.2015 (2015), p.224-230
Main Authors: Liu, Yu, Lin, Xiao, Lu, Tao, Geng, Haijiang, Yan, Fang-Rong
Format: Article
Language:English
Subjects:
Algorithms
Classification
Crystal structure
Datasets
Methods
Neural networks
Pharmaceuticals
Protein-protein interactions
Proteins
Solvents
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Summary:Protein functions through interactions with other proteins and biomolecules and these interactions occur on the so-called interface residues of the protein sequences. Identifying interface residues makes us better understand the biological mechanism of protein interaction. Meanwhile, information about the interface residues contributes to the understanding of metabolic, signal transduction networks and indicates directions in drug designing. In recent years, researchers have focused on developing new computational methods for predicting protein interface residues. Here we creatively used a 181-dimension protein sequence feature vector as input to the Naive Bayes Classifier- (NBC-) based method to predict interaction sites in protein-protein complexes interaction. The prediction of interaction sites in protein interactions is regarded as an amino acid residue binary classification problem by applying NBC with protein sequence features. Independent test results suggested that Naive Bayes Classifier-based method with the protein sequence features as input vectors performed well.
ISSN:2090-2247
2090-2255
DOI:10.1155/2015/978193