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An FDA-Drug Library Screen for Compounds with Bioactivities against Meticillin-Resistant Staphylococcus aureus (MRSA)

The lack of new antibacterial drugs entering the market and their misuse have resulted in the emergence of drug-resistant bacteria, posing a major health crisis worldwide. In particular, meticillin-resistant Staphylococcus aureus (MRSA), a pathogen responsible for numerous human infections, has beco...

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Published in:Antibiotics (Basel) 2015-10, Vol.4 (4), p.424-434
Main Authors: Lau, Qiu Ying, Tan, Yoke Yan Fion, Goh, Vanessa Chai Yin, Lee, David Jing Qin, Ng, Fui Mee, Ong, Esther H Q, Hill, Jeffrey, Chia, Cheng San Brian
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cited_by cdi_FETCH-LOGICAL-c468t-9073ff899a01dd65340e7060c39d7bdc487a04d74804b8e5578be1e98a74b7d03
cites cdi_FETCH-LOGICAL-c468t-9073ff899a01dd65340e7060c39d7bdc487a04d74804b8e5578be1e98a74b7d03
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container_title Antibiotics (Basel)
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creator Lau, Qiu Ying
Tan, Yoke Yan Fion
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Chia, Cheng San Brian
description The lack of new antibacterial drugs entering the market and their misuse have resulted in the emergence of drug-resistant bacteria, posing a major health crisis worldwide. In particular, meticillin-resistant Staphylococcus aureus (MRSA), a pathogen responsible for numerous human infections, has become endemic in hospitals worldwide. Drug repurposing, the finding of new therapeutic indications for approved drugs, is deemed a plausible solution to accelerate drug discovery and development in this area. Towards this end, we screened 1163 drugs approved by the Food and Drug Administration (FDA) for bioactivities against MRSA in a 10 μM single-point assay. After excluding known antibiotics and antiseptics, six compounds were identified and their MICs were determined against a panel of clinical MRSA strains. A toxicity assay using human keratinocytes was also conducted to gauge their potential for repurposing as topical agents for treating MRSA skin infections.
doi_str_mv 10.3390/antibiotics4040424
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subjects drug library screen
drug repositioning
drug repurposing
MRSA
title An FDA-Drug Library Screen for Compounds with Bioactivities against Meticillin-Resistant Staphylococcus aureus (MRSA)
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