Data on miRNome changes in human cells exposed to nano- or ionic- forms of Cadmium

• Published in: Data in brief 2020-06, Vol.30, p.105636, Article 105636
• Main Authors: Paesano, Laura, Marmiroli, Marta, Bianchi, Massimiliano G., White, Jason C., Bussolati, Ovidio, Zappettini, Andrea, Villani, Marco, Marmiroli, Nelson
• Format: Article
• Language: English
• Subjects: Biochemistry, Genetics and Molecular Biology; CdS quantum dots; HepG2; miRNAs as biomarkers; THP-1
• ISSN: 2352-3409; 2352-3409
• DOI: 10.1016/j.dib.2020.105636

The data included in this paper are associated with a research article entitled 'Differences in toxicity, mitochondrial function and miRNome in human cells exposed in vitro to Cd as CdS quantum dots or ionic Cd' [1]. The article concerns the use of miRNAs as biomarkers for engineered nanomaterials (ENMs) risk assessment. Two different type of human cells, HepG2 and THP-1, were exposed to different forms of Cadmium: nanoscale, as CdS quantum dots (CdS QDs), and ionic, as CdSO4 8/3 –hydrate (Cd(II)). The cells were treated with sub-toxic doses of CdS QDs; 3 µg ml−1 in HepG2 and 6.4 µg ml−1 and 50 µg ml−1 in THP-1, as well as equivalent cadmium doses as Cd(II). In this dataset, changes in expression levels of miRNAs are reported. In addition, GO enrichment analyses of target genes of miRNAs modulated by Cd stress, network analysis of the microRNome and an in silico pathway analysis are also reported. These data enhance and also summarize much of the data independently presented in the research article and therefore, must be considered as supplementary.