Cancer Microenvironment and Endoplasmic Reticulum Stress Response

Different stressful conditions such as hypoxia, nutrient deprivation, pH changes, or reduced vascularization, potentially able to act as growth-limiting factors for tumor cells, activate the unfolded protein response (UPR). UPR is therefore involved in tumor growth and adaptation to severe environme...

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Published in:Mediators of Inflammation 2015-01, Vol.2015 (2015), p.936-946-189
Main Authors: Filippini, Antonio, Facchiano, Antonio, Conti, Silvia, Petrungaro, Simonetta, Giampietri, Claudia, Ziparo, Elio
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Cancer therapies
Cell cycle
Endoplasmic reticulum
Endoplasmic Reticulum Stress - physiology
Health aspects
Histology
Homeostasis
Humans
Kinases
Male
Melanoma
Melanoma - metabolism
Observations
Physiology
Prostatic Neoplasms - metabolism
Protein folding
Protein synthesis
Review
Sensors
Stress response
Studies
Transcription factors
Tumor Microenvironment - physiology
Tumors
Unfolded Protein Response - physiology
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container_issue 2015
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creator Filippini, Antonio
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Ziparo, Elio
description Different stressful conditions such as hypoxia, nutrient deprivation, pH changes, or reduced vascularization, potentially able to act as growth-limiting factors for tumor cells, activate the unfolded protein response (UPR). UPR is therefore involved in tumor growth and adaptation to severe environments and is generally cytoprotective in cancer. The present review describes the molecular mechanisms underlying UPR and able to promote survival and proliferation in cancer. The critical role of UPR activation in tumor growth promotion is discussed in detail for a few paradigmatic tumors such as prostate cancer and melanoma.
doi_str_mv 10.1155/2015/417281
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subjects Animals
Apoptosis
Cancer therapies
Cell cycle
Endoplasmic reticulum
Endoplasmic Reticulum Stress - physiology
Health aspects
Histology
Homeostasis
Humans
Kinases
Male
Melanoma
Melanoma - metabolism
Observations
Physiology
Prostatic Neoplasms - metabolism
Protein folding
Protein synthesis
Review
Sensors
Stress response
Studies
Transcription factors
Tumor Microenvironment - physiology
Tumors
Unfolded Protein Response - physiology
title Cancer Microenvironment and Endoplasmic Reticulum Stress Response
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