Evaluation of Early Markers of Nephropathy in Patients with Type 2 Diabetes Mellitus

Aims. T2DM often remains undiagnosed for many years because hyperglycemia develops gradually and may not produce any symptoms. As patients with T2DM are at increased risk of microvascular and macrovascular complications, the preclinical diagnosis of the state is the key point of the disease manageme...

Full description

Saved in:
Bibliographic Details
Published in:Biochemistry Research International 2016-01, Vol.2016 (2016), p.287-292
Main Authors: Formato, Marilena, Lobina, Omar, Tram Nguyen, Hai Quy, Idini, Michela, Nieddu, Gabriele, Lepedda, Antonio Junior, De Muro, Pierina, Fresu, Pietro
Format: Article
Language:English
Subjects:
Chondroitin sulfate
Diabetes
Diabetic nephropathies
Diagnosis
Hypertension
Inflammation
Kidney diseases
Metabolic disorders
Neutrophils
Physiological aspects
Rodents
Urine
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aims. T2DM often remains undiagnosed for many years because hyperglycemia develops gradually and may not produce any symptoms. As patients with T2DM are at increased risk of microvascular and macrovascular complications, the preclinical diagnosis of the state is the key point of the disease management. Methods. We evaluated parameters such as GAGs/PGs, NAG, and NGAL in urine samples from 43 normoalbuminuric T2DM patients and 31 apparently healthy control subjects. Results. The total urinary GAG excretion showed no significant differences between patients and controls. The electrophoretic analysis evidenced the presence of UTI and its degradation products (LSC and SM-LSC), CS, and HS. We observed modifications of HS and total UTI (including UTI and its degradation products) relative contents in T2DM patients compared with controls whereas no differences in CS percentage were found. NGAL levels were significantly increased in T2DM patients and were positively correlated with both NAG (r=0.606, p
ISSN:2090-2247
2090-2255
DOI:10.1155/2016/7497614