Cerebral Microvascular and Systemic Effects Following Intravenous Administration of the Perfluorocarbon Emulsion Perftoran

Oxygen-carrying perfluorocarbon (PFC) fluids have the potential to increase tissue oxygenation during hypoxic states and to reduce ischemic cell death. Regulatory approval of oxygen therapeutics was halted due to concerns over vasoconstrictive side effects. The goal of this study was to assess the p...

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Bibliographic Details
Published in:Journal of functional biomaterials 2016-11, Vol.7 (4), p.29-29
Main Authors: Abutarboush, Rania, Saha, Biswajit K, Mullah, Saad H, Arnaud, Francoise G, Haque, Ashraful, Aligbe, Chioma, Pappas, Georgina, Auker, Charles R, McCarron, Richard M, Moon-Massat, Paula F, Scultetus, Anke H
Format: Article
Language:English
Subjects:
Arterioles
Biomaterials
Blood pressure
Cell death
cerebral microcirculation
Diameters
Government regulations
Hypoxia
Intravenous administration
intravital microscopy
Ischemia
Microvasculature
Oxygen
oxygen therapeutic
Oxygenation
perfluorocarbon (PFC)
Perfluorocarbons
Regulatory approval
Rodents
Saline
Side effects
Surgical implants
Vasoactive agents
Vasoconstriction
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Summary:Oxygen-carrying perfluorocarbon (PFC) fluids have the potential to increase tissue oxygenation during hypoxic states and to reduce ischemic cell death. Regulatory approval of oxygen therapeutics was halted due to concerns over vasoconstrictive side effects. The goal of this study was to assess the potential vasoactive properties of Perftoran by measuring brain pial arteriolar diameters in a healthy rat model. Perftoran, crystalloid (saline) or colloid (Hextend) solutions were administered as four sequential 30 min intravenous (IV) infusions, thus allowing an evaluation of cumulative dose-dependent effects. There were no overall changes in diameters of small-sized (
ISSN:2079-4983
2079-4983
DOI:10.3390/jfb7040029