Konjac flour-mediated gut microbiota alleviates insulin resistance and improves placental angiogenesis of obese sows

• Published in: AMB Express 2023-12, Vol.13 (1), p.143-143, Article 143
• Main Authors: Wu, Deyuan, Xiong, Wenyu, Ma, Shuo, Luo, Jinxi, Ye, Hongxuan, Huang, Shuangbo, Li, Fuyong, Xiang, Xi’en, Chen, Qiling, Gao, Binghui, Deng, Jinping, Yin, Yulong, Tan, Chengquan
• Format: Article
• Language: English
• Subjects: Angiogenesis; Biomedical and Life Sciences; Biotechnology; Diet; Fecal microbiota transplantation; Fecal microflora; Females; Flour; Hogs; Homeostasis; Insulin; Insulin resistance; Intestinal microflora; Konjac flour; Life Sciences; Microbial Genetics and Genomics; Microbiology; Microbiota; Microorganisms; Original; Original Article; Placenta; Placental angiogenesis; Protein expression; Proteins; SCFA; Swine; Transplantation
• ISSN: 2191-0855; 2191-0855
• DOI: 10.1186/s13568-023-01646-4

Our previous study revealed that dietary konjac flour (KF) could remodel gut microbiota and improve reproductive performance of sows, but its underlying mechanisms remain unclear. This experiment aimed to investigate how dietary KF improves reproductive performance of obese sows. Here, 60 sows were assigned into three groups according to their backfat thickness: normal backfat sows fed with control diet (CON-N), high backfat sows fed with control diet (CON-H) and high backfat sows fed with KF inclusion diet (KF-H). The characteristics of sows and piglets were recorded. Next, fecal microbiota transplantation (FMT) was performed on female mice, followed by recording the characteristics of female mice. The results showed that compared with CON-H group, KF-H group showed downtrend in stillbirth rate ( P  = 0.07), an increase in placental efficiency ( P