Light-dark dependence of electrocardiographic changes during asphyxia and reoxygenation in a rat model

The aim of this study was to evaluate the effect of ventilation on electrocardiographic time intervals as a function of the light-dark (LD) cycle in an in vivo rat model. RR, PQ, QT and QTc intervals were measured in female Wistar rats anaesthetized with both ketamine and xylazine (100 mg/15 mg/kg,...

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Bibliographic Details
Published in:Central European journal of medicine 2010-10, Vol.5 (5), p.611-619
Main Authors: Bačová, Ivana, Švorc, Pavol Jr, Kundrík, Martin, Fulton, Benjamin L
Format: Article
Language:English
Subjects:
Asphyxia
Biomedicine
Chronobiology
ECG
Internal Medicine
Maternal and Child Health
Medicine
Medicine & Public Health
Myocardium
Rat
rats
Reproductive Medicine
Research Article
Surgery
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Summary:The aim of this study was to evaluate the effect of ventilation on electrocardiographic time intervals as a function of the light-dark (LD) cycle in an in vivo rat model. RR, PQ, QT and QTc intervals were measured in female Wistar rats anaesthetized with both ketamine and xylazine (100 mg/15 mg/kg, i.m., open chest experiments) after adaptation to the LD cycle (12:12h) for 4 weeks. Electrocardiograms (ECG) were recorded before surgical interventions; after tracheotomy, and thoracotomy, and 5 minutes of stabilization with artificial ventilation; 30, 60, 90 and 120 seconds after the onset of apnoea; and after 5, 10, 15, and 20 minutes of artificial reoxygenation. Time intervals in intact animals showed significant LD differences, except in the QT interval. The initial significant (p
ISSN:1895-1058
2391-5463
1644-3640
2391-5463
DOI:10.2478/s11536-010-1038-1