An fMRI study of finger movements in children with and without dyslexia

Developmental dyslexia is a language-based reading disability, yet some have reported motor impairments, usually attributed to cerebellar dysfunction. Using fMRI, we compared children with and without dyslexia during irregularly paced, left or right-hand finger tapping. Next, we examined seed-to-vox...

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Bibliographic Details
Published in:Frontiers in neuroscience 2023-05, Vol.17, p.1135437-1135437
Main Authors: Turesky, Ted K, Luetje, Megan M, Eden, Guinevere F
Format: Article
Language:English
Subjects:
Attention deficit hyperactivity disorder
Brain
Brain mapping
Brain research
Cerebellum
Children
connectivity
Disability
Dyslexia
finger
Functional magnetic resonance imaging
Hand
Hands
Language
Learning disabilities
Medical imaging
Meta-analysis
motor
Motor systems
Motor task performance
Neural networks
Neurodevelopmental disorders
Neuroimaging
Neuroscience
Phonology
Postcentral gyrus
reading
Reading ability
Reading comprehension
Reading disabilities
reading disability
Thalamus
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Summary:Developmental dyslexia is a language-based reading disability, yet some have reported motor impairments, usually attributed to cerebellar dysfunction. Using fMRI, we compared children with and without dyslexia during irregularly paced, left or right-hand finger tapping. Next, we examined seed-to-voxel intrinsic functional connectivity (iFC) using six seed regions of the motor system (left and right anterior lobe of the cerebellum, SM1 and SMA). A whole-brain task-evoked analysis revealed relatively less activation in the group with dyslexia in right anterior cerebellum during right hand tapping. For iFC, we found the group with dyslexia to have greater iFC between the right SM1 seed and a medial aspect of right postcentral gyrus for left hand tapping; and greater iFC between the left SM1 seed and left thalamus, as well as weaker local iFC around the left SM1 seed region for right hand tapping. Lastly, extracted activity and connectivity values that had been identified in these between-group comparisons were not correlated with measures of reading. We conclude that there are some aberrations in motor system function in children with dyslexia, but these are not tied to reading ability.
ISSN:1662-4548
1662-453X
1662-453X
DOI:10.3389/fnins.2023.1135437