Force transduction by cadherin adhesions in morphogenesis [version 1; peer review: 3 approved]

Mechanical forces drive the remodeling of tissues during morphogenesis. This relies on the transmission of forces between cells by cadherin-based adherens junctions, which couple the force-generating actomyosin cytoskeletons of neighboring cells. Moreover, components of cadherin adhesions adopt forc...

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Bibliographic Details
Published in:F1000 research 2019, Vol.8, p.1044
Main Authors: Pannekoek, Willem-Jan, de Rooij, Johan, Gloerich, Martijn
Format: Article
Language:English
Subjects:
Actomyosin
Adherens junctions
Binding sites
Cadherins
Cell adhesion & migration
Cell cycle
Cell division
Cell migration
Cytoskeleton
Growth factors
Kinases
Mechanotransduction
Medical research
Morphogenesis
Proteins
Review
Signal transduction
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Summary:Mechanical forces drive the remodeling of tissues during morphogenesis. This relies on the transmission of forces between cells by cadherin-based adherens junctions, which couple the force-generating actomyosin cytoskeletons of neighboring cells. Moreover, components of cadherin adhesions adopt force-dependent conformations that induce changes in the composition of adherens junctions, enabling transduction of mechanical forces into an intracellular response. Cadherin mechanotransduction can mediate reinforcement of cell-cell adhesions to withstand forces but also induce biochemical signaling to regulate cell behavior or direct remodeling of cell-cell adhesions to enable cell rearrangements. By transmission and transduction of mechanical forces, cadherin adhesions coordinate cellular behaviors underlying morphogenetic processes of collective cell migration, cell division, and cell intercalation. Here, we review recent advances in our understanding of this central role of cadherin adhesions in force-dependent regulation of morphogenesis.
ISSN:2046-1402
2046-1402
DOI:10.12688/f1000research.18779.1