Prospective birth cohort in a hyperendemic dengue area in Northeast Brazil: methods and preliminary results

Dengue cases have increased in younger age groups in Brazil. Maternal anti-dengue antibodies can have a protective effect in the first months of life, but their decline can increase the risk of severe dengue. A prospective birth cohort was established in 2011-2012 in the city of Recife, Pernambuco S...

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Bibliographic Details
Published in:Cadernos de saúde pública 2016-01, Vol.32 (1)
Main Authors: Braga, Cynthia, Albuquerque, Maria de Fátima Pessoa Militão de, Cordeiro, Marli Tenório, Castanha, Priscila M S, Ramesh, Anita, Alexander, Neal, Mello, Maria Júlia G de, Marques, Jr, Ernesto T A, Martelli, Celina M Turchi
Format: Article
Language:English
Subjects:
Antibodies, Viral - blood
Brazil - epidemiology
Child, Preschool
Dengue
Dengue - epidemiology
Dengue - immunology
Dengue Virus - immunology
Endemic Diseases
Enzyme-Linked Immunosorbent Assay
Epidemiologic Methods
Estudios de Cohortes
Female
Humans
Immunity, Maternally-Acquired
Immunoglobulin G - blood
Immunoglobulin M - blood
Infant
Inmunización Pasiva
Male
PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
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Summary:Dengue cases have increased in younger age groups in Brazil. Maternal anti-dengue antibodies can have a protective effect in the first months of life, but their decline can increase the risk of severe dengue. A prospective birth cohort was established in 2011-2012 in the city of Recife, Pernambuco State, Brazil, to determine the incidence of serotype-specific dengue infection and the kinetics of transferred maternal anti-dengue antibodies in the first years of life. This article describes the design, methods and preliminary results of this cohort study. 354 children underwent clinical and laboratory monitoring for two years, with 15% losses to follow-up. The overall rate of new infections was approximately 10% in the first year of follow-up. Information on the force of serotype-specific dengue infection and the evaluation of transferred maternal antibodies can contribute to understanding dengue etiopathogenesis.
ISSN:0102-311X
1678-4464
1678-4464
0102-311X
DOI:10.1590/0102-311X00095815