The Role of Bioceramics for Bone Regeneration: History, Mechanisms, and Future Perspectives

Osteoporosis is a skeletal disorder marked by compromised bone integrity, predisposing individuals, particularly older adults and postmenopausal women, to fractures. The advent of bioceramics for bone regeneration has opened up auspicious pathways for addressing osteoporosis. Research indicates that...

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Published in:Biomimetics (Basel, Switzerland) Switzerland), 2024-04, Vol.9 (4), p.230
Main Authors: Tanvir, Md Amit Hasan, Khaleque, Md Abdul, Kim, Ga-Hyun, Yoo, Whang-Yong, Kim, Young-Yul
Format: Article
Language:English
Subjects:
Analysis
bioceramics
Biocompatibility
Biomedical materials
BMP
Bone diseases
Bone growth
Bone morphogenetic proteins
Bone regeneration
Calcium phosphates
Care and treatment
Ceramic materials
Ceramics
Diagnosis
Drug delivery systems
Fractures
Health aspects
Hydroxyapatite
Kinases
MAP kinase
MAPK
MSCs
Osteoporosis
Post-menopause
Prostheses
Protein kinases
Proteins
Regeneration
scaffold
Skin & tissue grafts
Stem cells
Tissue engineering
Transplants & implants
Wnt protein
β-Catenin
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Summary:Osteoporosis is a skeletal disorder marked by compromised bone integrity, predisposing individuals, particularly older adults and postmenopausal women, to fractures. The advent of bioceramics for bone regeneration has opened up auspicious pathways for addressing osteoporosis. Research indicates that bioceramics can help bones grow back by activating bone morphogenetic protein (BMP), mitogen-activated protein kinase (MAPK), and wingless/integrated (Wnt)/β-catenin pathways in the body when combined with stem cells, drugs, and other supports. Still, bioceramics have some problems, such as not being flexible enough and prone to breaking, as well as difficulties in growing stem cells and discovering suitable supports for different bone types. While there have been improvements in making bioceramics better for healing bones, it is important to keep looking for new ideas from different areas of medicine to make them even better. By conducting a thorough scrutiny of the pivotal role bioceramics play in facilitating bone regeneration, this review aspires to propel forward the rapidly burgeoning domain of scientific exploration. In the end, this appreciation will contribute to the development of novel bioceramics that enhance bone regrowth and offer patients with bone disorders alternative treatments.
ISSN:2313-7673
2313-7673
DOI:10.3390/biomimetics9040230